CAS Number96036-03-2
SynonymsSM 7338; MEROPENEM (PATENTED); Merrem; MEROPENAM; MeropeneM API; Meronem; MEROPENEM,USP; MeropeneM Crude; MEROPENEM, 1 G; Meropen; Meropenem; MFCD00864966
Molecular FormulaC17H25N3O5S
Molecular Weight383.47
Purity98%
Density1.4±0.1 g/cm3
Boiling Point627.4±55.0 °C at 760 mmHg
AppearanceLight yellow to gray brown powder or crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 96036-03-2 |
| Catalog No. | 2A-9011349 |
| Chinese Name | 美罗培南 |
| Synonyms | SM 7338; MEROPENEM (PATENTED); Merrem; MEROPENAM; MeropeneM API; Meronem; MEROPENEM,USP; MeropeneM Crude; MEROPENEM, 1 G; Meropen; Meropenem; MFCD00864966 |
| Molecular Formula | C17H25N3O5S |
| Molecular Weight | 383.47 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 627.4±55.0 °C at 760 mmHg |
| Appearance | Light yellow to gray brown powder or crystal |
| Storage Condition | -20°C, sealed, dry |
| Application | Meropenem is a carbapenem broad-spectrum antibiotic. |
| HTC | 2933990090 |
| MDL Number | C17H25N3O5S |
| SMILES | C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(O)=O)S[C@H]3CC[C@H](N3)C(=O)N(C)C |
| InChI | InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-10-6-5-9(18-10)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1 |
| InChI Key | InChIKey=FSTGLKRHSQANLP-PQTSNVLCSA-N |
| MSDS | msds/11349_1_96036_03_2.pdf |
| Bioactivity | Meropenem is a carbapenem antibiotic, which displaying a broad spectrum of antibacterial activity.Target: AntibacterialMeropenem, a new parenteral carbapenem demonstrated increased activity as compared to imipenem against 336 strains of Neisseria gonorrhoeae, 119 strains of Haemophilus influenzae, and 110 strains of H. Ceftriaxone and ciprofloxacin demonstrated activity superior to that of both carbapenems while the activity of ceftazidime was similar to that of meropenem [1]. Meropenem, like imipenem and various experimental penems, may overcome the resistance problems presented by Class I beta-lactamases [2]. MEROPENEM was rapidly penetrated to the pleural effusion and was retained for a more prolonged time in the pleural effusion than in the blood of patients with accumulated pleural effusion, and it suggested the usefulness of MEROPENEM in antibacterial therapy for patients with pleurisy causing accumulation of pleural effusion [3].Clinical indications: Appendicitis; Bacterial infection; Bacterial meningitis; Bacterial pneumonia; Bacterial respiratory tract infection; Bacterial skin infection; Bacterial urinary tract infection; Bacteroides fragilis infection; Bacteroides infection; Bacteroides thetaiotaomicron infection; Complicated skin and skin structure infectionFDA Approved Date: July 1996Toxicity: In mice and rats, large intravenous doses of meropenem (2200-4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Natural Products >> Alkaloid Research Areas >> Infection References [1]. Slaney, L., et al., In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother, 1989. 24 Suppl A: p. 183-6. [2]. Yang, Y.J. and D.M. Livermore, Interactions of meropenem with class I chromosomal beta-lactamases. J Antimicrob Chemother, 1989. 24 Suppl A: p. 207-17. [3]. Makino, J., et al., [Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy]. Jpn J Antibiot, 2002. 55(1): p. 77-88. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 627.4±55.0 °C at 760 mmHg Molecular Formula C17H25N3O5S Molecular Weight 383.462 Flash Point 333.2±31.5 °C Exact Mass 383.151489 PSA 135.48000 LogP -3.13 Vapour Pressure 0.0±4.2 mmHg at 25°C Index of Refraction 1.639 |
| Use of | Properties Name meropenem Synonym More Synonyms Meropenem Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Natural Products >> Alkaloid Research Areas >> Infection References [1]. Slaney, L., et al., In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother, 1989. 24 Suppl A: p. 183-6. [2]. Yang, Y.J. and D.M. Livermore, Interactions of meropenem with class I chromosomal beta-lactamases. J Antimicrob Chemother, 1989. 24 Suppl A: p. 207-17. [3]. Makino, J., et al., [Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy]. Jpn J Antibiot, 2002. 55(1): p. 77-88. Chemical & Physical Properties Molecular Formula C17H25N3O5S Exact Mass 383.151489 PSA 135.48000 LogP -3.13 Index of Refraction 1.639 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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