CAS Number59937-28-9
SynonymsMalotilatum [INN-Latin]; dipropan-2-yl 1,3-dithiol-2-ylidenepropanedioate; 1,3-Dithiol-2-ylidenepropanedioic Acid Bis(1-methylethyl) Ester; Malotilato [INN-Spanish]; NKK 105; Malotilate; Propanedioic acid, 2-(1,3-dithiol-2-ylidene)-, bis(1-methylethyl) ester; EINECS 261-987-3; MFCD00867646; CL-1500; Kantec; Diisopropyl 1,3-dithiol-2-ylidenemalonate
Molecular FormulaC12H16O4S2
Molecular Weight288.39
Purity98%
Density1.3±0.1 g/cm3
Boiling Point321.5±42.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59937-28-9 |
| Catalog No. | 2A-9011280 |
| Chinese Name | 马洛替酯 |
| Synonyms | Malotilatum [INN-Latin]; dipropan-2-yl 1,3-dithiol-2-ylidenepropanedioate; 1,3-Dithiol-2-ylidenepropanedioic Acid Bis(1-methylethyl) Ester; Malotilato [INN-Spanish]; NKK 105; Malotilate; Propanedioic acid, 2-(1,3-dithiol-2-ylidene)-, bis(1-methylethyl) ester; EINECS 261-987-3; MFCD00867646; CL-1500; Kantec; Diisopropyl 1,3-dithiol-2-ylidenemalonate |
| Molecular Formula | C12H16O4S2 |
| Molecular Weight | 288.39 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 321.5±42.0 °C at 760 mmHg |
| Storage Condition | -20°C |
| Application | Malotilate can act on liver cells, promote their RNA synthesis, activate ribosomes, improve protein synthesis capacity, thereby activating liver function and inhibiting liver fibrosis, and can also in |
| MDL Number | MFCD00867646 |
| SMILES | CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1 |
| InChI | InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3 |
| InChI Key | YPIQVCUJEKAZCP-UHFFFAOYSA-N |
| MSDS | msds/11280_1_59937_28_9.pdf |
| Bioactivity | Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase. IC50 Value:Target: 5-lipoxygenasein vitro: In an in vitro invasion assay using rat lung endothelial (RLE) cells, invasion of tumor cells which had been treated with MT (10 ng/ml, 24 h) was not affected; however, when RLE cells had been treated with MT, invasion was significantly inhibited in three cell lines (SAS, Ca9-22 and HSC-4) and a tendency to inhibition was also observed in other cell lines [1].in vivo: The improvement rates for choline esterase activity were significantly greater in the malotilate group than in the control group. Serum albumin levels significantly increased in the malotilate group but not in the control group [2]. In the rats treated with MT for 19 days after i.v. inoculation of c-SST-2 cells, lung metastasis was also significantly suppressed [3]. Malotilate prevented increases in serum markers of type III and IV collagen synthesis as well as accumulation of the collagens, laminin and fibronectin in the liver [4].Toxicity: Malotilate cytotoxicity to PBMCs, assessed by trypan blue dye exclusion and lactate dehydrogenase (LDH) release into the culture media, was found to be markedly increased by the addition of the NADPH generating system, indicating that metabolites play a significant role in toxicity [5]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Cancer Natural Products >> Others References [1]. Shibata T, et al. Inhibitory effects of malotilate on in vitro invasion of lung endothelial cell monolayer by human oral squamous cell carcinoma cells. Tumour Biol. 2000 Sep-Oct;21(5):299-308. [2]. Takase S, et al. Effects of malotilate treatment on alcoholic liver disease. Alcohol. 1989 May-Jun;6(3):219-22. [3]. Nagayasu H, et al. Inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. Br J Cancer. 1998 May;77(9):1371-7. [4]. Ryhanen L, et al. The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat. J Hepatol. 1996 Feb;24(2):238-45. [5]. Nomura F, et al. Detection of malotilate toxicity in vitro with peripheral blood mononuclear cells as targets. A preliminary report. J Hepatol. 1990 Jul;11(1):65-9. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 321.5±42.0 °C at 760 mmHg Molecular Formula C12H16O4S2 Molecular Weight 288.383 Flash Point 138.7±15.9 °C Exact Mass 288.049011 PSA 103.20000 LogP 3.83 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.562 InChIKey YPIQVCUJEKAZCP-UHFFFAOYSA-N SMILES CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1 Storage condition -20°C |
| Use of | Properties Name dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate Synonym More Synonyms Malotilate Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Cancer Natural Products >> Others References [1]. Shibata T, et al. Inhibitory effects of malotilate on in vitro invasion of lung endothelial cell monolayer by human oral squamous cell carcinoma cells. Tumour Biol. 2000 Sep-Oct;21(5):299-308. [2]. Takase S, et al. Effects of malotilate treatment on alcoholic liver disease. Alcohol. 1989 May-Jun;6(3):219-22. [3]. Nagayasu H, et al. Inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. Br J Cancer. 1998 May;77(9):1371-7. [4]. Ryhanen L, et al. The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat. J Hepatol. 1996 Feb;24(2):238-45. [5]. Nomura F, et al. Detection of malotilate toxicity in vitro with peripheral blood mononuclear cells as targets. A preliminary report. J Hepatol. 1990 Jul;11(1):65-9. Chemical & Physical Properties Molecular Formula C12H16O4S2 Exact Mass 288.049011 PSA 103.20000 Index of Refraction 1.562 InChIKey YPIQVCUJEKAZCP-UHFFFAOYSA-N SMILES CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1 |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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