CAS Number75695-93-1
SynonymsRebriden; DynaCirc; Esradin; Isrodipine; Presca; Dynacrine; MFCD00153820; Rebfiden; Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; Iomir; methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Clivoten; UNII:YO1UK1S598; Lomir; Methyl-1-methylethyl-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylat; Isradipine; methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Prescal; Isradipin
Molecular FormulaC19H21N3O5
Molecular Weight371.39
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point501.9±60.0 °C at 760 mmHg
Melting Point166-168°C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 75695-93-1 |
| Catalog No. | 2A-9011072 |
| Chinese Name | 伊拉地平 |
| Synonyms | Rebriden; DynaCirc; Esradin; Isrodipine; Presca; Dynacrine; MFCD00153820; Rebfiden; Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; Iomir; methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Clivoten; UNII:YO1UK1S598; Lomir; Methyl-1-methylethyl-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylat; Isradipine; methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Prescal; Isradipin |
| Molecular Formula | C19H21N3O5 |
| Molecular Weight | 371.39 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 501.9±60.0 °C at 760 mmHg |
| Melting Point | 166-168°C |
| Appearance | solid |
| Water Solubility | DMSO: ~26 mg/mL |
| Storage Condition | 2-8°C |
| Application | Isradipine (Dynacirc) is a calcium channel blocker with an IC50 of 34μM. |
| PubChem ID | 24724517 |
| MDL Number | MFCD00153820 |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C |
| InChI | 1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 |
| InChI Key | HMJIYCCIJYRONP-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/11072_1_75695_93_1.pdf |
| Bioactivity | Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Berjukow, S. and S. Hering, Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (-)-isradipine. Br J Pharmacol, 2001. 133(7): p. 959-66. [2]. Tran, P.H., et al., Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int J Pharm, 2013. 450(1-2): p. 79-86. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 501.9±60.0 °C at 760 mmHg Melting Point 166-168°C Molecular Formula C19H21N3O5 Molecular Weight 371.387 Flash Point 257.4±32.9 °C Exact Mass 371.148132 PSA 103.55000 LogP 3.59 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.566 InChIKey HMJIYCCIJYRONP-UHFFFAOYSA-N SMILES COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 Storage condition 2-8°C Water Solubility DMSO: ~26 mg/mL |
| Use of | Properties Articles49 Name Isradipine Synonym More Synonyms Isradipine Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [2]. Tran, P.H., et al., Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int J Pharm, 2013. 450(1-2): p. 79-86. Chemical & Physical Properties Molecular Formula C19H21N3O5 Exact Mass 371.148132 PSA 103.55000 Index of Refraction 1.566 InChIKey HMJIYCCIJYRONP-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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