CAS Number523-50-2
Synonyms2H-Furo[2,3-h][1]benzopyran-2-one; 4-Hydroxy-5-benzofuranacrylic acid γ-lactone; Furo[2,3-h]benzopyran-2-one; EINECS 201-480-6; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran,2H-Furo[2,3-h]-1-benzopyran-2-one; ISOPSORALENE; Isopsoralen; ANGELICINE; angecin; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 2H-Furo[2,3-h]-1-benzopyran-2-one; T B566 EO LVOJ; MFCD00064930; 2H-Furo[2,3-h]chromen-2-one; 2H-Furo[2,3-h]-1-benzopyran-2-one; isopsoralin; Angelicin; ISOBERGAPTEN
Molecular FormulaC11H6O3
Molecular Weight186.16
Purity98%
Density1.4±0.1 g/cm3
Boiling Point362.6±27.0 °C at 760 mmHg
Melting Point132-134ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 523-50-2 |
| Catalog No. | 2A-9011055 |
| Chinese Name | 异补骨脂素 |
| Synonyms | 2H-Furo[2,3-h][1]benzopyran-2-one; 4-Hydroxy-5-benzofuranacrylic acid γ-lactone; Furo[2,3-h]benzopyran-2-one; EINECS 201-480-6; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran,2H-Furo[2,3-h]-1-benzopyran-2-one; ISOPSORALENE; Isopsoralen; ANGELICINE; angecin; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran 2H-Furo[2,3-h]-1-benzopyran-2-one; T B566 EO LVOJ; MFCD00064930; 2H-Furo[2,3-h]chromen-2-one; 2H-Furo[2,3-h]-1-benzopyran-2-one; isopsoralin; Angelicin; ISOBERGAPTEN |
| Molecular Formula | C11H6O3 |
| Molecular Weight | 186.16 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 362.6±27.0 °C at 760 mmHg |
| Melting Point | 132-134ºC |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 |
| HTC | 2932999099 |
| PubChem ID | 24890472 |
| MDL Number | MFCD00064930 |
| SMILES | O=C1Oc2c(C=C1)ccc3occc23 |
| InChI | 1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H |
| InChI Key | XDROKJSWHURZGO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 153970 |
| NACRES Code | NA.25 |
| UNSPSC | 85151701 |
| Hazard Symbols | Transport |
| MSDS | msds/11055_1_523_50_2.pdf |
| Bioactivity | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3].In vivo: Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Md. Ataur Rahman, Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Molecular and Cellular Biochemistry October 2012, Volume 369, Issue 1-2, pp 95-104 [2]. Hye-Jeong Cho, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Research Volume 100, Issue 1, October 2013, Pages 75-83 [3]. Fang Liu, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Journal of Surgical Research Volume 185, Issue 1, November 2013, Pages 300-309 Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 362.6±27.0 °C at 760 mmHg Melting Point 132-134ºC Molecular Formula C11H6O3 Molecular Weight 186.163 Flash Point 173.1±23.7 °C Exact Mass 186.031693 PSA 43.35000 LogP 2.01 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.667 InChIKey XDROKJSWHURZGO-UHFFFAOYSA-N SMILES O=c1ccc2ccc3occc3c2o1 Storage condition 2-8°C |
| Use of | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3].In vivo: Properties Articles28 Name angelicin Synonym More Synonyms Angelicin Biological Activity Description Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM (cellular cytotoxicity); 5.39 μg/ml (28.95 μM) (against MHV-68)Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells [2]. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways [3].In vivo: Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Phenylpropanoids References [1]. Md. Ataur Rahman, Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Molecular and Cellular Biochemistry October 2012, Volume 369, Issue 1-2, pp 95-104 [2]. Hye-Jeong Cho, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Research Volume 100, Issue 1, October 2013, Pages 75-83 [3]. Fang Liu, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Journal of Surgical Research Volume 185, Issue 1, November 2013, Pages 300-309 Chemical & Physical Properties Molecular Formula C11H6O3 Exact Mass 186.031693 PSA 43.35000 Index of Refraction 1.667 InChIKey XDROKJSWHURZGO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Botanical Reference Standards | ||
|---|---|---|
| Homoorientin | 4261-42-1 | 2A-9010857 |
| Hyperoside | 482-36-0 | 2A-9010877 |
| Icariin | 489-32-7 | 2A-9010885 |
| Imperatorin | 482-44-0 | 2A-9010933 |
| Isobergapten | 482-48-4 | 2A-9011041 |
| Isoquercitrin | 21637-25-2 | 2A-9011057 |
| Isorhamnetin | 480-19-3 | 2A-9011058 |
| kaempferol-3,7-di-O-glucoside | 2A-302168 | 2A-9011085 |
| Kaempferol-3-glucuronide | 2A-302169 | 2A-9011086 |
| Kaempferol-3-O-sophoroside-O-glucoside | 2A-302170 | 2A-9011087 |
| Browse all Botanical Reference Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS