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Irsogladine maleate structure, CAS 84504-69-8

Irsogladine maleate

CAS Number84504-69-8

Synonyms1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1); MN 1695 {Maleate}; MFCD00873566; Irsogladine maleate; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine (2Z)-2-butenedioate (1:1); 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine (2Z)-but-2-enedioate (1:1); (Z)-but-2-enedioic acid,6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine

Molecular FormulaC13H11O4N5Cl2

Molecular Weight372.17

Purity98%

Density

Boiling Point552.2ºC at 760 mmHg

Melting Point181-182°C

Flash Point

AppearanceWhite-off-white crystal-powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9011032 Purity: 98%
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Quality Control of [ 84504-69-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number84504-69-8
Catalog No.2A-9011032
Chinese Name马来酸伊索拉定
Synonyms1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1); MN 1695 {Maleate}; MFCD00873566; Irsogladine maleate; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine (2Z)-2-butenedioate (1:1); 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine (2Z)-but-2-enedioate (1:1); (Z)-but-2-enedioic acid,6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
Molecular FormulaC13H11O4N5Cl2
Molecular Weight372.17
Purity98
Boiling Point552.2ºC at 760 mmHg
Melting Point181-182°C
AppearanceWhite-off-white crystal-powder
Storage ConditionDesiccate at RT
ApplicationIrsogladine maleate is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
HTC2933699090
MDL NumberMFCD00873566
SMILESNc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1.O=C(O)C=CC(=O)O
InChIInChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI KeyPJLVTVAIERNDEQ-BTJKTKAUSA-N
MSDSmsds/11032_1_84504_69_8.pdf
BioactivityIrsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Target: PDE4; mACHRIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology References [1]. Ren, C.J., et al., Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res, 1998. 77(2): p. 126-31. [2]. Kawasaki, Y., et al., Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002. 25(4): p. 373-7. [3]. Kyoi, T., et al., Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci, 2004. 75(15): p. 1833-42. Chemical & Physical Properties Boiling Point 552.2ºC at 760 mmHg Melting Point 181-182°C Molecular Formula C13H11Cl2N5O4 Molecular Weight 372.164 Flash Point 287.8ºC Exact Mass 371.018799 PSA 165.31000 LogP 2.88400 InChIKey PJLVTVAIERNDEQ-BTJKTKAUSA-N SMILES Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1.O=C(O)C=CC(=O)O Storage condition Desiccate at RT
Use ofProperties Name Irsogladine maleate Synonym More Synonyms Irsogladine Maleate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology References [1]. Ren, C.J., et al., Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res, 1998. 77(2): p. 126-31. [2]. Kawasaki, Y., et al., Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002. 25(4): p. 373-7. [3]. Kyoi, T., et al., Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci, 2004. 75(15): p. 1833-42. Chemical & Physical Properties Exact Mass 371.018799 PSA 165.31000 LogP 2.88400 InChIKey PJLVTVAIERNDEQ-BTJKTKAUSA-N Storage condition Desiccate at RT
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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