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Ingenol structure, CAS 30220-46-3

Ingenol

CAS Number30220-46-3

Synonymsingenol; MFCD00056380

Molecular FormulaC20H28O5

Molecular Weight348.44

Purity98%

Density1.3±0.1 g/cm3

Boiling Point523.8±50.0 °C at 760 mmHg

Melting Point153 °C

Flash Point

AppearanceSolid;White to Almost white powder to crystal

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Cat. No.: 2A-9010952 Purity: 98%
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Quality Control of [ 30220-46-3 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number30220-46-3
Catalog No.2A-9010952
Chinese Name巨大戟二萜醇
Synonymsingenol; MFCD00056380
Molecular FormulaC20H28O5
Molecular Weight348.44
Purity98
Density1.3±0.1 g/cm3
Boiling Point523.8±50.0 °C at 760 mmHg
Melting Point153 °C
AppearanceSolid;White to Almost white powder to crystal
Storage ConditionSealed in a cool, dry environment at -20 ºC
ApplicationIngenol is a PKC activator with a Ki value of 30 μM and anti-tumor activity.
MDL NumberMFCD27980538
SMILESCC1=CC23C(=O)C(C=C(CO)C(O)C2(O)C1O)C1C(CC3C)C1(C)C
InChI KeyVEBVPUXQAPLADL-WOVWOYSOSA-N
Hazard SymbolsTransport
MSDSmsds/10952_1_30220_46_3.pdf
BioactivityIngenol is a PKC activator, with a Ki of 30 μM, with antitumor activity. Related Catalog Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Target PKC:30 μM (Ki) In Vitro Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication[1]. References [1]. Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 523.8±50.0 °C at 760 mmHg Melting Point 153 °C Molecular Formula C20H28O5 Molecular Weight 348.433 Flash Point 284.7±26.6 °C Exact Mass 348.193665 PSA 97.99000 LogP 2.95 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.625 InChIKey VEBVPUXQAPLADL-WOVWOYSOSA-N SMILES CC1=CC23C(=O)C(C=C(CO)C(O)C2(O)C1O)C1C(CC3C)C1(C)C
Use ofIngenol is a PKC activator, with a Ki of 30 μM, with antitumor activity. Properties Name ingenol Synonym More Synonyms Ingenol Biological Activity Description Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity. Related Catalog Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer PKC:30 μM (Ki) References [1]. Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8. Chemical & Physical Properties Molecular Formula C20H28O5 Exact Mass 348.193665 PSA 97.99000 Index of Refraction 1.625 InChIKey VEBVPUXQAPLADL-WOVWOYSOSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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