CAS Number26844-12-2
Synonyms3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol; Indoramine [INN-French]; N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide; 3-[2-(4-benzamido-1-piperidyl)ethyl]indole; INDORAMIN; Indoramine; 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole; Indoramina [INN-Spanish]; EINECS 248-041-5; Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl); Indoraminum [INN-Latin]
Molecular FormulaC22H25N3O
Molecular Weight383.91
Purity≥98 (HPLC)%
Density1.21g/cm3
Boiling Point600ºC at 760mmHg
Melting Point208-210°
Appearancesolid
EINECS254-136-2
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26844-12-2 |
| Catalog No. | 2A-9010948 |
| Chinese Name | 吲哌胺 |
| Synonyms | 3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol; Indoramine [INN-French]; N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide; 3-[2-(4-benzamido-1-piperidyl)ethyl]indole; INDORAMIN; Indoramine; 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole; Indoramina [INN-Spanish]; EINECS 248-041-5; Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl); Indoraminum [INN-Latin] |
| Molecular Formula | C22H25N3O |
| Molecular Weight | 383.91 |
| Purity | ≥98 (HPLC) |
| Density | 1.21g/cm3 |
| Boiling Point | 600ºC at 760mmHg |
| Melting Point | 208-210° |
| Appearance | solid |
| Application | Indomethacin is an orally active antihypertensive drug. Indomethacin is also selective for α1A adrenergic receptors [1]. |
| EINECS | 254-136-2 |
| HTC | 2933990090 |
| PubChem ID | 24724512 |
| MDL Number | MFCD00242842 |
| SMILES | [Cl].O=C(NC1CCN(CC1)CCc2c[nH]c3ccccc23)c4ccccc4 |
| InChI | 1S/C22H25N3O.Cl/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21;/h1-9,16,19,23H,10-15H2,(H,24,26); |
| InChI Key | NZEVFUHXTSASST-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/10948_1_26844_12_2.pdf |
| Use of | Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1]. Properties Name N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide Synonym More Synonyms Indoramin Biological Activity Description Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor References [1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. Chemical & Physical Properties Molecular Formula C22H25N3O Exact Mass 347.20000 PSA 48.13000 LogP 3.93360 Index of Refraction 1.657 InChIKey JXZZEXZZKAWDSP-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)- CAS REGISTRY NUMBER : 26844-12-2 BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H25-N3-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971 Safety Information HS Code 2933990090 Precursor & DownStream Precursor 1 CAS#:26844-47-3 N-[1-[2-(1H-ind... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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