CAS Number21187-73-5
SynonymsGardenin A; 5OH3'4'5'6,7,8-hexMeO-Flavone; 3',4',5',6,7,8-Hexamethoxy-5-hydroxyflavone; Gardenin; 5-hydroxy-6,7,8,3',4',5'-hexamethoxyflavone; Flavone,5-hydroxy-3',4',5',6,7,8-hexamethoxy
Molecular FormulaC21H22O9
Molecular Weight418.39
Purity≥90.0 (HPLC)%
Density1.3g/cm3
Boiling Point624.2ºC at 760 mmHg
Melting Point162-163ºC
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21187-73-5 |
| Catalog No. | 2A-9010695 |
| Chinese Name | 栀子(黄)素A |
| Synonyms | Gardenin A; 5OH3'4'5'6,7,8-hexMeO-Flavone; 3',4',5',6,7,8-Hexamethoxy-5-hydroxyflavone; Gardenin; 5-hydroxy-6,7,8,3',4',5'-hexamethoxyflavone; Flavone,5-hydroxy-3',4',5',6,7,8-hexamethoxy |
| Molecular Formula | C21H22O9 |
| Molecular Weight | 418.39 |
| Purity | ≥90.0 (HPLC) |
| Density | 1.3g/cm3 |
| Boiling Point | 624.2ºC at 760 mmHg |
| Melting Point | 162-163ºC |
| Storage Condition | -20°C |
| Application | Gardenin A is an orally active and synthetic PMF analogue with neurotrophic effects on neurite growth and neuronal differentiation. Gardenin A promotes the occurrence of neuritis by activating MAPK/ER |
| HTC | 2914509090 |
| MDL Number | MFCD00017419 |
| SMILES | [o]1c2c([c](cc1c3cc(c(c(c3)OC)OC)OC)=O)c(c(c(c2OC)OC)OC)O |
| InChI | 1S/C21H22O9/c1-24-13-7-10(8-14(25-2)17(13)26-3)12-9-11(22)15-16(23)19(27-4)21(29-6)20(28-5)18(15)30-12/h7-9,23H,1-6H3 |
| InChI Key | MQBFFYQCZCKSBX-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| MSDS | msds/10695_1_21187_73_5.pdf |
| Use of | Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2]. Properties Name 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one Synonym More Synonyms Gardenin A Biological Activity Description Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2]. Related Catalog Signaling Pathways >> Cytoskeleton >> PAK Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PAK Signaling Pathways >> Stem Cell/Wnt >> ERK References [2]. Alonso-Castro AJ, et al. Evaluation of the neuropharmacological effects of Gardenin A in mice. Drug Dev Res. 2020 Aug;81(5):600-608. Chemical & Physical Properties Molecular Formula C21H22O9 Exact Mass 418.12600 PSA 105.82000 LogP 3.21720 Index of Refraction 1.573 InChIKey MQBFFYQCZCKSBX-UHFFFAOYSA-N Safety Information Hazard Codes T+ HS Code 2914509090 Synthetic Route Total: 1 Page 4H-1-Benzopyran... CAS#:6965-36-2 Gardenin A CAS#:21187-73-5 Literature: Banerji, J.; Das, B.; Chakrabarty, R.; Jha, H. C. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 597 - 599 Precursor & DownStream Precursor 1 CAS#:6965-36-2 4H-1-Benzopyran... DownStream 1 CAS#:6965-36-2 4H-1-Benzopyran... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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