| Chemical & Physical Properties | |
|---|---|
| CAS Number | 16662-47-8 |
| Catalog No. | 2A-9010680 |
| Chinese Name | 戈洛帕米 |
| Synonyms | MFCD00058000; 5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile |
| Molecular Formula | C28H40N2O5 |
| Molecular Weight | 521.09 |
| Purity | ≥98 |
| Density | 1.068g/cm3 |
| Boiling Point | 605.9ºC at 760mmHg |
| Storage Condition | -20°C |
| Application | Gallopamil (Methoxyverapamil) is a methoxy derivative of verapamil and a phenylalkylamine calcium antagonist. Gallopamil acts on the vascular system, heart and its lymphatic structures. Gallopamil inh |
| PubChem ID | 24277852 |
| MDL Number | MFCD00058000 |
| SMILES | Cl[H].COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC |
| InChI | 1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H |
| InChI Key | OKCRIUNHEQSXFD-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10680_1_16662_47_8.pdf |
| Bioactivity | Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil acts on the vascular system and the heart and nodal structure[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease Target Ca2+ References [1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. [2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. Chemical & Physical Properties Density 1.068g/cm3 Boiling Point 605.9ºC at 760mmHg Molecular Formula C28H40N2O5 Molecular Weight 521.08900 Flash Point 320.2ºC Exact Mass 520.27000 PSA 73.18000 LogP 5.66408 Vapour Pressure 1.25E-14mmHg at 25°C Index of Refraction 1.523 InChIKey XQLWNAFCTODIRK-UHFFFAOYSA-N SMILES COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC Storage condition -20°C |
| Use of | Properties Articles25 Name 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile Synonym More Synonyms Gallopamil Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. [2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. Chemical & Physical Properties Molecular Formula C28H40N2O5 Exact Mass 520.27000 PSA 73.18000 LogP 5.66408 Index of Refraction 1.523 InChIKey XQLWNAFCTODIRK-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a guarantee as to the properties of this product. The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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