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Flucloxacillin sodium structure, CAS 1847-24-1

Flucloxacillin sodium

CAS Number1847-24-1

SynonymsEINECS 217-428-0; MFCD01682108; Flucloxacillin sodium

Molecular FormulaC19H16ClFN3NaO5S

Molecular Weight475.85

Purity98%

Density

Boiling Point677.3ºC at 760 mmHg

Melting Point176-178ºC

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

SymbolTransport

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Cat. No.: 2A-9010543 Purity: 98%
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Quality Control of [ 1847-24-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1847-24-1
Catalog No.2A-9010543
Chinese Name氟氯西林钠
SynonymsEINECS 217-428-0; MFCD01682108; Flucloxacillin sodium
Molecular FormulaC19H16ClFN3NaO5S
Molecular Weight475.85
Purity98
Boiling Point677.3ºC at 760 mmHg
Melting Point176-178ºC
Appearancepowder
Storage Condition-20°C Freezer
ApplicationFlucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria.
MDL NumberMFCD01682108
SMILESCC1(C)[C@H](C([O-])=O)N2C([C@@H](NC(C3=C(C)ON=C3C4=C(F)C=CC=C4Cl)=O)[C@@]2([H])S1)=O.[Na+]
InChI1S/C19H17ClFN3O5S.Na/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);/q;+1/p-1/t13-,14+,17-;/m1./s1
InChI KeyOTEANHMVDHZOPB-SLINCCQESA-M
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/10543_1_1847_24_1.pdf
BioactivityFlucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Target Bacterial[1] In Vivo The serum elimination half-life of flucloxacillin is 1.31-1.39 hours, and six hours after administration of a single 250 mg dose the serum concentration of flucloxacillin is 0.46 micrograms/mL[1]. Oral flucloxacillin does not affect sweat electrolytes and is not a contraindication to sweat testing[2]. Flucloxacillin has been reported to be metabolized in man to the penicilloic acid, the antibacterially active 5'-hydroxymethyl derivative and the penicilloic acid of the 5'-hydroxymethyl derivative. The metabolism of flucloxacillin in the rat is similar[3]. Animal Admin Rats: On the day of the experiment the animal is given an intravenous bolus injection of 200 mg/kg as pure free acid sodium flucloxacillin (dose volume: 1 mL sterile water per kg) and then return to the metabolism cage. Urine is collected directly into individual CO2 cooled containers for a period of 24 h before dosing and then at frequent intervals after dosing[3]. References [1]. Paton DM, et al. Bioavailability and half-life of two preparations of flucloxacillin. N Z Med J. 1982 Nov 10;95(719):766-8. [2]. Williams J, et al.Sweat tests and flucloxacillin. Arch Dis Child. 1988 Jul;63(7):847-8. [3]. Everett JR, et al. 19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine. J Pharm Pharmacol. 1985 Dec;37(12):869-73. Chemical & Physical Properties Boiling Point 677.3ºC at 760 mmHg Melting Point 176-178ºC Molecular Formula C19H16ClFN3NaO5S Molecular Weight 475.854 Flash Point 363.4ºC Exact Mass 475.038086 PSA 140.87000 LogP 1.68190 Vapour Pressure 2.86E-19mmHg at 25°C InChIKey PWDULVAXRLDWLM-SLINCCQESA-N SMILES Cc1onc(-c2c(F)cccc2Cl)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)O.[Na] Storage condition -20°C Freezer
Use ofFlucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria. Properties Name flucloxacillin sodium Synonym More Synonyms Flucloxacillin sodium Biological Activity Description Flucloxacillin sodium is a highly active antibiotic against Gram-positive and Gram-negative bacteria. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Bacterial[1] References [1]. Paton DM, et al. Bioavailability and half-life of two preparations of flucloxacillin. N Z Med J. 1982 Nov 10;95(719):766-8. [2]. Williams J, et al.Sweat tests and flucloxacillin. Arch Dis Child. 1988 Jul;63(7):847-8. [3]. Everett JR, et al. 19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine. J Pharm Pharmacol. 1985 Dec;37(12):869-73. Chemical & Physical Properties Exact Mass 475.038086 PSA 140.87000 LogP 1.68190 InChIKey PWDULVAXRLDWLM-SLINCCQESA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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