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Fenobam structure, CAS 57653-26-6

Fenobam

CAS Number57653-26-6

SynonymsMcn-3377; N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea; 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea; N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea; 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea; [3H]-Fenobam; N-3-chlorophenyl-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea

Molecular FormulaC11H11ClN4O2

Molecular Weight266.68

Purity≥98 (HPLC)%

Density1.47 g/cm3

Boiling Point

Melting Point

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9010476 Purity: ≥98 (HPLC)%
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Quality Control of [ 57653-26-6 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number57653-26-6
Catalog No.2A-9010476
Chinese Name非诺班
SynonymsMcn-3377; N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea; 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea; N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea; 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea; [3H]-Fenobam; N-3-chlorophenyl-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
Molecular FormulaC11H11ClN4O2
Molecular Weight266.68
Purity≥98 (HPLC)
Density1.47 g/cm3
Appearancesolid
Storage Condition2-8°C
ApplicationFenobam is a selective, orally active, noncompetitive mGluR5 antagonist that acts at the allosteric regulatory site (Kd values ​​of 54 nM and 31 nM at rat and human recombinant mGlu5 receptors, respec
PubChem ID24894721
MDL NumberMFCD00868019
SMILESCN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2
InChI1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
InChI KeyDWPQODZAOSWNHB-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/10476_1_57653_26_6.pdf
BioactivityFenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease Target rat mGluR5:54 nM (Kd) human mGluR5:31 nM (Kd) References [1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383; Chemical & Physical Properties Density 1.47 g/cm3 Molecular Formula C11H11ClN4O2 Molecular Weight 266.68400 Exact Mass 266.05700 PSA 73.80000 LogP 1.12690 Index of Refraction 1.668 InChIKey DWPQODZAOSWNHB-UHFFFAOYSA-N SMILES CN1CC(=O)NC1=NC(=O)Nc1cccc(Cl)c1 Storage condition 2-8°C
Use ofFenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity[1][2]. Properties Articles24 Name fenobam Synonym More Synonyms Fenobam Biological Activity Description Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease rat mGluR5:54 nM (Kd) human mGluR5:31 nM (Kd) References [1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383; Chemical & Physical Properties Exact Mass 266.05700 PSA 73.80000 LogP 1.12690 Index of Refraction 1.668 InChIKey DWPQODZAOSWNHB-UHFFFAOYSA-N
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