CAS Number130495-35-1
SynonymsUNII:33BI32858P; 1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1); MFCD00236407; 1-{2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride (1:1); SKF 96365; SKF-96365 hydrochloride; SKF 96365 HCI
Molecular FormulaC22H27ClN2O3
Molecular Weight402.91
Purity≥98 (HPLC)%
Boiling Point556ºC at 760mmHg
Melting Point119 °C
Appearancesolid
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130495-35-1 |
| Catalog No. | 2A-0104215 |
| Chinese Name | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 |
| Synonyms | UNII:33BI32858P; 1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1); MFCD00236407; 1-{2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride (1:1); SKF 96365; SKF-96365 hydrochloride; SKF 96365 HCI |
| Molecular Formula | C22H27ClN2O3 |
| Molecular Weight | 402.91 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 556ºC at 760mmHg |
| Melting Point | 119 °C |
| Appearance | solid |
| Water Solubility | H2O: >20 mg/mL |
| Storage Condition | Keep the container sealed and stored in a cool, dr |
| Application | SKF-96365 hydrochloride is a non-selective TRP channel inhibitor. |
| EINECS | 0 |
| HTC | 2933290090 |
| UN(IATA) | 0 |
| PubChem ID | 24278710 |
| MDL Number | MFCD00236407 |
| SMILES | Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1 |
| InChI | 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H |
| InChI Key | FWLPKVQUECFKSW-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/104215_1_130495_35_1.pdf |
| Bioactivity | SKF-96365 hydrochloride is a non-selective TRP Channel blocker. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Target TRP Channel[1] In Vitro SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. In Vivo SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2]. Animal Admin Mice: Five to six-week-old female athymic BALB/c mice are inoculated into the right oxter with HCT116 cells. When the diameter of the subcutaneous tumor reaches approximately 0.5 cm, animals are randomLy assigned to the vehicle, SKF-96365 alone, HCQ alone or SKF-96365+HCQ. SKF-96365 is applied (20 mg/kg) and HCQ is applied (60 mg/kg) daily for 14 successive days by i.p. injection. Tumor sizes and volume are determined. Eight mice are included in each group. Mice are sacrificed 24 h after the last treatment. The tumors are weighed and processed for western blot analysis or paraffin embedding[2]. References [1]. Liu H, et al. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. Pharmacological Research. Pharmacol Res, 2016 Feb, 104:61-9. [2]. Jing Z, et al. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett, 2016 Mar 28, 372(2):226-38. Chemical & Physical Properties Boiling Point 556ºC at 760mmHg Melting Point 119 °C Molecular Formula C22H27ClN2O3 Molecular Weight 402.914 Flash Point 290.1ºC Exact Mass 402.171021 PSA 45.51000 LogP 5.09300 Appearance of Characters solid | white Vapour Pressure 7.86E-12mmHg at 25°C InChIKey FWLPKVQUECFKSW-UHFFFAOYSA-N SMILES COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1.Cl Storage condition Store at RT Water Solubility H2O: >20 mg/mL |
| Use of | SKF-96365 hydrochloride is a non-selective TRP Channel blocker. Properties Articles13 Name 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole,hydrochloride Synonym More Synonyms SKF-96365 Biological Activity Description SKF-96365 hydrochloride is a non-selective TRP Channel blocker. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer TRP Channel[1] In Vivo SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2]. References [2]. Jing Z, et al. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett, 2016 Mar 28, 372(2):226-38. Chemical & Physical Properties Exact Mass 402.171021 PSA 45.51000 LogP 5.09300 Appearance of Characters solid | white InChIKey FWLPKVQUECFKSW-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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