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Etilefrine hydrochloride structure, CAS 943-17-9

Etilefrine hydrochloride

CAS Number943-17-9

Synonymsetilefrine hydrochloride; Effortil; α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride; N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride; 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride; Thomasin; Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1); Effortil*HCl; EINECS 213-398-8; Etilefrin-HCl; 3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1); Etilefrin dl-form hydrochloride; Cardanat; Etilefrine HCl; Effontil; Efortil; Circupon

Molecular FormulaC10H16ClNO2

Molecular Weight217.69

Purity≥95%

Density1.127g/cm3

Boiling Point351.7ºC at 760 mmHg

Melting Point121 °C

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9010412 Purity: ≥95%
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Quality Control of [ 943-17-9 ] Purity: ≥95% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number943-17-9
Catalog No.2A-9010412
Chinese Name盐酸依替福林
Synonymsetilefrine hydrochloride; Effortil; α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride; N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride; 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride; Thomasin; Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1); Effortil*HCl; EINECS 213-398-8; Etilefrin-HCl; 3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1); Etilefrin dl-form hydrochloride; Cardanat; Etilefrine HCl; Effontil; Efortil; Circupon
Molecular FormulaC10H16ClNO2
Molecular Weight217.69
Purity≥95
Density1.127g/cm3
Boiling Point351.7ºC at 760 mmHg
Melting Point121 °C
Water SolubilityFreely soluble in water, soluble in ethanol (96 pe
Storage ConditionRoom Temperature
ApplicationAtileline hydrochloride is an orally active alpha-adrenergic agonist. Etilerine hydrochloride is also an AMPK activator. Etilerin hydrochloride can be used in the study of orthostatic hypotension [1][
HTC2922509090
SMILESCl.OC1=CC=CC(=C1)C(O)CNCC
InChIInChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H
InChI KeyKTNROWWHOBZQGK-UHFFFAOYSA-N
NACRES CodeNA.21
UNSPSC51101500
MSDSmsds/10412_1_943_17_9.pdf
BioactivityEtilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension[1][2][3][4]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> PI3K/Akt/mTOR >> AMPK References [1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24. [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5. [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24. [4]. Bouaggad A, et al. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000 Mar;17(3):177-81. Chemical & Physical Properties Density 1.127g/cm3 Boiling Point 351.7ºC at 760 mmHg Melting Point 122ºC Molecular Formula C10H16ClNO2 Molecular Weight 217.69 Flash Point 155.5ºC Exact Mass 217.086960 PSA 52.49000 LogP 2.22800 InChIKey KTNROWWHOBZQGK-UHFFFAOYSA-N SMILES CCNCC(O)c1cccc(O)c1.Cl Water Solubility Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
Use ofEtilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension[1][2][3][4]. Properties Articles24 Name 3-[2-(ethylamino)-1-hydroxyethyl]phenol,hydrochloride Synonym More Synonyms Efortil Biological Activity Description Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension[1][2][3][4]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> PI3K/Akt/mTOR >> AMPK References [1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24. [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5. [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24. [4]. Bouaggad A, et al. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000 Mar;17(3):177-81. Chemical & Physical Properties Exact Mass 217.086960 PSA 52.49000 LogP 2.22800 InChIKey KTNROWWHOBZQGK-UHFFFAOYSA-N Water Solubility Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
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