CAS Number7414-83-7
SynonymsDisodium (1-hydroxy-1,1-ethanediyl)bis[hydrogen (phosphonate)]; EINECS 231-025-7; Disodium Etidronate Hydrate; MFCD00152567; Didronel; Dinatrium-(1-hydroxyethan-1,1-diyl)bis[hydrogen-(phosphonat)]; 1-Hydroxyethylidene-1,1-diphosphonic acid disodium salt; Etidronate disodium; Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]; Phosphonic acid, (1-hydroxyethylidene)bis-, sodium salt (1:2); disodium etidronate; Disodium (1-hydroxyethylidene)diphosphonate; disodium,hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate; Disodium 1-hydroxyethylidene phosphonate; (1-Hydroxyethylidene)diphosphonic acid, disodium salt; (1-hydroxyéthane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium
Molecular FormulaC2H6Na2O7P2
Molecular Weight249.99 (anhydrous basis)
Purity≥97 (NMR)%
Boiling Point578.8ºC at 760 mmHg
Melting Point>300 °C
Appearancesolid
EINECS231-025-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7414-83-7 |
| Catalog No. | 2A-9010410 |
| Chinese Name | 羟乙膦酸钠 |
| Synonyms | Disodium (1-hydroxy-1,1-ethanediyl)bis[hydrogen (phosphonate)]; EINECS 231-025-7; Disodium Etidronate Hydrate; MFCD00152567; Didronel; Dinatrium-(1-hydroxyethan-1,1-diyl)bis[hydrogen-(phosphonat)]; 1-Hydroxyethylidene-1,1-diphosphonic acid disodium salt; Etidronate disodium; Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]; Phosphonic acid, (1-hydroxyethylidene)bis-, sodium salt (1:2); disodium etidronate; Disodium (1-hydroxyethylidene)diphosphonate; disodium,hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate; Disodium 1-hydroxyethylidene phosphonate; (1-Hydroxyethylidene)diphosphonic acid, disodium salt; (1-hydroxyéthane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium |
| Molecular Formula | C2H6Na2O7P2 |
| Molecular Weight | 249.99 (anhydrous basis) |
| Purity | ≥97 (NMR) |
| Boiling Point | 578.8ºC at 760 mmHg |
| Melting Point | >300 °C |
| Appearance | solid |
| Water Solubility | H2O: 26 mg/mL | Soluble in water (26 mg/ml). |
| Storage Condition | Sealed in a cool, dry environment at 2-8ºC. |
| Application | Atidronate disodium is an orally and intravenously active bisphosphonate. Altidronate disodium inhibits bone resorption, reduces arterial calcification, and can be used in osteoporosis research. Etidr |
| EINECS | 231-025-7 |
| PubChem ID | 329820220 |
| MDL Number | MFCD00152567 |
| SMILES | [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O |
| InChI | 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2 |
| InChI Key | GWBBVOVXJZATQQ-UHFFFAOYSA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/10410_1_7414_83_7.pdf |
| Bioactivity | Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease In Vitro Etidronic acid (Etidronate) (10 mM, 24 h) disodium shows cytotoxicity, causes a decrease in the S-phase population and an increase in the G2/M population, induces p53 mutation in MCF-7 cells[3]. Etidronic acid (100 nM, 24 h) disodium induces osteoclast apoptosis, which displays characteristics of apoptosis, including chromatin condensation and changed cellular and nuclear morphology, detected by fluorescence microscopy[5]. References [1]. Dunn CJ, et al. Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging. 1994 Dec;5(6):446-74. [2]. Ariyoshi T, et al. Effect of etidronic acid on arterial calcification in dialysis patients. Clin Drug Investig. 2006;26(4):215-22. [3]. Zhou Y, et al. Cytotoxicity of etidronic acid to human breast cancer cells. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-87-92. [4]. Zhu S, et al. In-Depth Study of Heavy Metal Removal by an Etidronic Acid-Functionalized Layered Double Hydroxide. ACS Appl Mater Interfaces. 2022 Feb 9;14(5):7450-7463. [5]. Kameda T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997 Aug 18;186(4):489-95. Chemical & Physical Properties Boiling Point 578.8ºC at 760 mmHg Melting Point > 300ºC Molecular Formula C2H6Na2O7P2 Molecular Weight 249.992 Flash Point 303.8ºC Exact Mass 249.938416 PSA 160.57000 InChIKey GWBBVOVXJZATQQ-UHFFFAOYSA-L SMILES CC(O)(P(=O)([O-])O)P(=O)([O-])O.[Na+].[Na+] Storage condition 2-8°C Water Solubility H2O: 26 mg/mL | Soluble in water (26 mg/ml). |
| Use of | Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4]. Properties Name etidronate disodium Synonym More Synonyms Etidronate disodium Biological Activity Description Etidronic acid (Etidronate) disodium is an orally and intravenously active bisphosphonate. Etidronic acid disodium inhibits resorption of bone, reduces arterial calcification and can be used for osteoporosis research. Etidronic acid disodium has anticancer activity. Etidronic acid disodium is a chelating agent and can be used to remove heavy metal in water[1][2][3][4]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Metabolic Disease References [1]. Dunn CJ, et al. Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs Aging. 1994 Dec;5(6):446-74. [2]. Ariyoshi T, et al. Effect of etidronic acid on arterial calcification in dialysis patients. Clin Drug Investig. 2006;26(4):215-22. [3]. Zhou Y, et al. Cytotoxicity of etidronic acid to human breast cancer cells. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-87-92. [4]. Zhu S, et al. In-Depth Study of Heavy Metal Removal by an Etidronic Acid-Functionalized Layered Double Hydroxide. ACS Appl Mater Interfaces. 2022 Feb 9;14(5):7450-7463. [5]. Kameda T, et al. Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997 Aug 18;186(4):489-95. Chemical & Physical Properties Molecular Formula C2H6Na2O7P2 Exact Mass 249.938416 PSA 160.57000 InChIKey GWBBVOVXJZATQQ-UHFFFAOYSA-L SMILES CC(O)(P(=O)([O-])O)P(=O)([O-])O.[Na+].[Na+] |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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