CAS Number16595-80-5
Synonyms(-)-Tetramisole hydrochloride; Solaskil; Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-, hydrochloride (1:1); Spartakon; Levamisol hydrochloride; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazolhydrochlorid; (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride; Ascaridil; Levasole; Meglum; Levadin; MFCD00005536; (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride; L[-]-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride; Decaris; L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride; Nilverm; Ripercol; L(−)
Molecular FormulaC11H13ClN2S
Molecular Weight240.75
Purity≥99 (GC)%
Boiling Point344.4ºC at 760 mmHg
Melting Point228-230 °C
Appearancepowder
EINECS240-654-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 16595-80-5 |
| Catalog No. | 2A-9010363 |
| Chinese Name | 盐酸左旋咪唑 |
| Synonyms | (-)-Tetramisole hydrochloride; Solaskil; Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-, hydrochloride (1:1); Spartakon; Levamisol hydrochloride; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazolhydrochlorid; (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride; Ascaridil; Levasole; Meglum; Levadin; MFCD00005536; (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride; L[-]-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride; Decaris; L-(-)-2,3,5,6-Tetrahydro-6-phenyl-imidazo(2,1-b)thiazole hydrochloride; (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole monohydrochloride; Nilverm; Ripercol; L(−) |
| Molecular Formula | C11H13ClN2S |
| Molecular Weight | 240.75 |
| Purity | ≥99 (GC) |
| Boiling Point | 344.4ºC at 760 mmHg |
| Melting Point | 228-230 °C |
| Appearance | powder |
| Water Solubility | Water solubility: soluble |
| Storage Condition | 2~8°C |
| Packaging | III |
| Application | Levamisole hydrochloride is an anthelmintic and immunomodulator. |
| EINECS | 240-654-6 |
| HTC | 2933290090 |
| PubChem ID | 24278526 |
| MDL Number | MFCD00012675 |
| SMILES | Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3 |
| InChI | 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1 |
| InChI Key | LAZPBGZRMVRFKY-HNCPQSOCSA-N |
| Beilstein/REAXYS | 4358988 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/10363_1_16595_80_5.pdf |
| Bioactivity | Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Neurological Disease References [1]. Centers for Disease Control and Prevention (CDC). Agranulocytosis associated with cocaine use - four States, March 2008-November 2009.MMWR Morb Mortal Wkly Rep. 2009 Dec 18;58(49):1381-5. [2]. Zhu NY, et al. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med. 2009 Feb 17;150(4):287-9. [3]. Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. Chemical & Physical Properties Boiling Point 344.4ºC at 760 mmHg Melting Point 226-231ºC Molecular Formula C11H13ClN2S Molecular Weight 240.752 Flash Point 162.1ºC Exact Mass 240.048798 PSA 40.90000 LogP 2.32160 Index of Refraction -126 ° (C=1， H2O) InChIKey LAZPBGZRMVRFKY-HNCPQSOCSA-N SMILES Cl.c1ccc(C2CN3CCSC3=N2)cc1 Storage condition 2~8°C |
| Use of | Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging. Properties Articles49 Name Levamisole hydrochloride Synonym More Synonyms Levamisole (hydrochloride) Biological Activity Description Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Neurological Disease References [1]. Centers for Disease Control and Prevention (CDC). Agranulocytosis associated with cocaine use - four States, March 2008-November 2009.MMWR Morb Mortal Wkly Rep. 2009 Dec 18;58(49):1381-5. [2]. Zhu NY, et al. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med. 2009 Feb 17;150(4):287-9. [3]. Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. Chemical & Physical Properties Exact Mass 240.048798 PSA 40.90000 LogP 2.32160 InChIKey LAZPBGZRMVRFKY-HNCPQSOCSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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