CAS Number164656-23-9
Synonyms(5a,17b)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; (5α,17β)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Duagen; α,α,α,α',α',α'-Hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide; Dutasteride; a,a,a,a',a',a'-Hexafluoro-3-oxo-4-aza-5a-androst-1-ene-17b-carboxy-2',5'-xylidide
Molecular FormulaC27H30O2N2F6
Molecular Weight528.54
Purity98%
Density1.3±0.1 g/cm3
Boiling Point620.3±55.0 °C at 760 mmHg
Melting Point242-250ºC
AppearanceWhite crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 164656-23-9 |
| Catalog No. | 2A-0200630 |
| Chinese Name | 度他雄胺 |
| Synonyms | (5a,17b)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; (5α,17β)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Duagen; α,α,α,α',α',α'-Hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide; Dutasteride; a,a,a,a',a',a'-Hexafluoro-3-oxo-4-aza-5a-androst-1-ene-17b-carboxy-2',5'-xylidide |
| Molecular Formula | C27H30O2N2F6 |
| Molecular Weight | 528.54 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 620.3±55.0 °C at 760 mmHg |
| Melting Point | 242-250ºC |
| Appearance | White crystalline solid |
| Water Solubility | DMSO: soluble2mg/mL, clear |
| Storage Condition | -20°C Freezer |
| Packaging | 1kg/aluminium can |
| Application | Dutasteride (GG745) is a 5α reductase isoenzyme inhibitor and may also have off-target effects on the androgen receptor (AR) due to its similarity to the DHT domain. |
| HTC | 2942000000 |
| MDL Number | MFCD00937869 |
| SMILES | CC12C=CC(=O)NC1CCC1C2CCC2(C)C(C(=O)Nc3cc(C(F)(F)F)ccc3C(F)(F)F)CCC12 |
| InChI | InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17?,19+,21+,24-,25+/m0/s1 |
| InChI Key | JWJOTENAMICLJG-QWBYCMEYSA-N |
| MSDS | msds/10266_1_164656_23_9.pdf |
| Use of | Properties Articles14 Name dutasteride Synonym More Synonyms Dutasteride Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> 5 alpha Reductase Research Areas >> Cancer References [1]. Lazier CB, et al. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58(2):130-44. [2]. Biancolella M, et al. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7. [3]. Bramson HN, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther. 1997 Sep;282(3):1496-502. [4]. Andriole GL, et al. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol. 2006 May;175(5):1657-62. [5]. Margiotta-Casaluci L, et al. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat Toxicol. 2013 Mar 15;128-129:113-23. Chemical & Physical Properties Molecular Formula C27H30F6N2O2 Exact Mass 528.221130 PSA 58.20000 Index of Refraction 1.523 InChIKey JWJOTENAMICLJG-QWBYCMEYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2942000000 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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