| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66611-37-8 |
| Catalog No. | 2A-0102495 |
| Chinese Name | (Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐 |
| Synonyms | BGP-15; (Z)-N'-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotiniMidaMide |
| Molecular Formula | C14H24Cl2N4O2 |
| Molecular Weight | 351.27 |
| Purity | ≥98 (HPLC) |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | BGP-15 is a PARP inhibitor with IC50 and Ki values of 120 and 57 μM, respectively. |
| EINECS | 0 |
| HTC | 2933399090 |
| UN(IATA) | 0 |
| PubChem ID | 329773244 |
| MDL Number | MFCD21603901 |
| SMILES | Cl.Cl.N\C(=N/OCC(O)CN1CCCCC1)c2cccnc2 |
| InChI | 1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H |
| InChI Key | ISGGVCWFTPTHIX-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/102495_1_66611_37_8.pdf |
| Use of | BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively. Properties Name N-(2-Hydroxy-3-(piperidin-1-yl)propoxy)-nicotinimidamide dihydrochloride Synonym More Synonyms BGP-15 Biological Activity Description BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively. Related Catalog Research Areas >> Cardiovascular Disease PARP:120 μM (IC50) In Vitro BGP-15 (200 μM) prevents the imatinib mesylate-induced oxidative damages, attenuates the depletion of high-energy phosphates, alters the signaling effect of imatinib mesylate by preventing p38 MAP kinase and JNK activation, and induced the phosphorylation of Akt and GSK-3beta[5]. References [1]. Kennedy TL, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016 Dec;186(12):3246-3260. [2]. Salah H, et al. The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction. Sci Transl Med. 2016 Aug 3;8(350):350ra103 [3]. Sapra G, et al. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice. Nat Commun. 2014 Dec 9;5:5705. [4]. Literati-Nagy B, et al. Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies. Metab Syndr Relat Disord. 2014 Mar;12(2):125-31. [5]. Sarszegi Z, et al. BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37. [6]. Szabados E, et al. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem Pharmacol. 2000 Apr 15;59(8):937-45. Chemical & Physical Properties Exact Mass 350.12800 PSA 81.47000 LogP 2.80750 InChIKey ISGGVCWFTPTHIX-UHFFFAOYSA-N Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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