| Chemical & Physical Properties | |
|---|---|
| CAS Number | 627908-92-3 |
| Catalog No. | 2A-0102478 |
| Chinese Name | SU14813 |
| Synonyms | SU14813 |
| Molecular Formula | C23H27O4N4F1 |
| Molecular Weight | 442.49 |
| Purity | 96+ |
| Storage Condition | 2-8℃ |
| Application | SU14813 is a multi-target receptor tyrosine kinase inhibitor with IC50 values of 50, 2, 4 and 15 nM for inhibiting VEGFR2, VEGFR1, PDGFRβ and KIT respectively. |
| EINECS | 0 |
| HTC | 2934999090 |
| UN(IATA) | 0 |
| MDL Number | MFCD19704841 |
| SMILES | Cc1[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCC(O)CN1CCOCC1 |
| InChI Key | CTNPALGJUAXMMC-INIZCTEOSA-N |
| MSDS | msds/102478_1_627908_92_3.pdf |
| Use of | SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT. Properties Name 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[ 2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carb oxamide Synonym More Synonyms SU14813 Biological Activity Description SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Research Areas >> Cancer VEGFR1:2 nM (IC50) VEGFR2:50 nM (IC50) PDGFRβ:4 nM (IC50) KIT:15 nM (IC50) In Vivo SU14813 inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion. The plasma concentration required for in vivo target inhibition is estimated to be 100 to 200 ng/mL. Used as monotherapy, SU14813 exhibits broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduces growth of various established xenografts derived from human or rat tumor cell lines. Treatment in combination with docetaxel significantly enhances both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone[1]. References [1]. Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82. Chemical & Physical Properties Molecular Formula C23H27FN4O4 Exact Mass 442.20200 PSA 113.67000 LogP 2.28400 InChIKey CTNPALGJUAXMMC-INIZCTEOSA-N Storage condition 2-8℃ Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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