| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117857-45-1 |
| Catalog No. | 2A-0102431 |
| Chinese Name | 氯瑞唑 |
| Synonyms | Sodium phosphate monobasic; Loreclezole; LoreclezoleHCl |
| Molecular Formula | C10H6Cl3N3 |
| Molecular Weight | 274.53 |
| Purity | ≥98 (HPLC) |
| Density | 1.48g/cm3 |
| Boiling Point | 418.7ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Loreclezole is an anti-epileptic drug that is a selective modulator of GABAA receptors and a positive allosteric modulator of receptors containing β2 or β3 subunits. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00865331 |
| SMILES | Cl/C(C1=CC=C(Cl)C=C1Cl)=C\N2N=CN=C2 |
| InChI | 1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4- |
| InChI Key | XGLHZTBDUXXHOM-WMZJFQQLSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| MSDS | msds/102431_1_117857_45_1.pdf |
| Use of | Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2]. Properties Name Loreclezole hydrochloride,(Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazolehydrochloride Synonym More Synonyms Loreclezole Biological Activity Description Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor GABAA receptor[1]. References [1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. Chemical & Physical Properties Exact Mass 272.96300 PSA 30.71000 LogP 3.77930 Index of Refraction 1.65 InChIKey XGLHZTBDUXXHOM-WMZJFQQLSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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