CAS Number117704-25-3
SynonymsDoromectin; Doramectina; Doramectin; 25-cyclohexyl-avermectin B1; DONGGUAI.P.E; Dectoma; Dectomax; 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a; Doramecin
Molecular FormulaC50H74O14
Molecular Weight899.114
Purity98%
Density1.3±0.1 g/cm3
Boiling Point967.4±65.0 °C at 760 mmHg
Melting Point116 - 119ºC
AppearanceWhite to off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 117704-25-3 |
| Catalog No. | 2A-9010232 |
| Chinese Name | 多拉菌素 |
| Synonyms | Doromectin; Doramectina; Doramectin; 25-cyclohexyl-avermectin B1; DONGGUAI.P.E; Dectoma; Dectomax; 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a; Doramecin |
| Molecular Formula | C50H74O14 |
| Molecular Weight | 899.114 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 967.4±65.0 °C at 760 mmHg |
| Melting Point | 116 - 119ºC |
| Appearance | White to off-white crystalline powder |
| Water Solubility | methanol: soluble |
| Storage Condition | 0-6°C |
| Application | Doramectin has antiparasitic activity. |
| SMILES | COC1CC(OC2C(C)OC(OC3C(C)=CCC4CC(CC5(C=CC(C)C(C6CCCCC6)O5)O4)OC(=O)C4C=C(C)C(O)C5OCC(=CC=CC3C)C45O)CC2OC)OC(C)C1O |
| InChI | InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44?,45-,46?,47+,49+,50+/m0/s1 |
| InChI Key | QLFZZSKTJWDQOS-TTXKVKCHSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/10232_1_117704_25_3.pdf |
| Bioactivity | Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol. [2]. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295. [3]. Sarre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T. Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium. Vet Parasitol. 2012 Apr 30;185(2-4):346-51. [4]. Lobetti R. .Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. [5]. Wang JB, Pan HX, Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3320-3. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 967.4±65.0 °C at 760 mmHg Melting Point 116 - 119ºC Molecular Formula C50H74O14 Molecular Weight 899.114 Flash Point 274.4±27.8 °C Exact Mass 898.507874 PSA 170.06000 LogP 7.16 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.580 InChIKey QLFZZSKTJWDQOS-TTXKVKCHSA-N SMILES COC1CC(OC2C(C)OC(OC3C(C)=CCC4CC(CC5(C=CC(C)C(C6CCCCC6)O5)O4)OC(=O)C4C=C(C)C(O)C5OCC(=CC=CC3C)C45O)CC2OC)OC(C)C1O Storage condition 0-6°C Water Solubility methanol: soluble |
| Use of | Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. Properties Articles28 Name doramectin Synonym More Synonyms Doramectin Biological Activity Description Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol. [3]. Sarre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T. Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium. Vet Parasitol. 2012 Apr 30;185(2-4):346-51. [4]. Lobetti R. .Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. [5]. Wang JB, Pan HX, Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3320-3. Chemical & Physical Properties Molecular Formula C50H74O14 Exact Mass 898.507874 PSA 170.06000 Index of Refraction 1.580 InChIKey QLFZZSKTJWDQOS-TTXKVKCHSA-N Water Solubility methanol: soluble |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Doramectin) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Doramectin) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Doramectin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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