EN
0
Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (S)-2-AMINO-6-(2-HYDROXYPROPANOYL)-7,8-DIHYDROPTERIDIN-4(3H)-ONE
(S)-2-AMINO-6-(2-HYDROXYPROPANOYL)-7,8-DIHYDROPTERIDIN-4(3H)-ONE structure, CAS 17094-01-8

(S)-2-AMINO-6-(2-HYDROXYPROPANOYL)-7,8-DIHYDROPTERIDIN-4(3H)-ONE

CAS Number17094-01-8

Synonyms2-amino-6-(2-hydroxy-propionyl)-7,8-dihydro-3H-pteridin-4-one; MFCD00210214; 1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone; 2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)-Pteridinone; 2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone; (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone; Sepiapterine; L-Sepiapterin; Sepiapterin,S-()-2-Amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-pteridinone,L-Sepiapterin; 2-Amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-4(1H)-pteridinone; Sepiapterin; 2-Amino-6-L-lactoyl-7,8-dihydro-3H-pteridin-4-on; 2-amino-6-(2-hydroxypropanoyl)-7,8-dihydro-1H-pty oeridin-4-one; 2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE; 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-1H-pteridin

Molecular FormulaC9H11N5O3

Molecular Weight237.215

Purity96+%

Density1.9±0.1 g/cm3

Boiling Point448.1ºC at 760 mmHg

Melting Point> 275 °C (lit.)

Flash Point

Appearanceyellow solid

EINECS0

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1101314 Purity: 96+%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 17094-01-8 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number17094-01-8
Catalog No.2A-1101314
Chinese Name墨蝶呤
Synonyms2-amino-6-(2-hydroxy-propionyl)-7,8-dihydro-3H-pteridin-4-one; MFCD00210214; 1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone; 2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)-Pteridinone; 2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone; (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone; Sepiapterine; L-Sepiapterin; Sepiapterin,S-()-2-Amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-pteridinone,L-Sepiapterin; 2-Amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-4(1H)-pteridinone; Sepiapterin; 2-Amino-6-L-lactoyl-7,8-dihydro-3H-pteridin-4-on; 2-amino-6-(2-hydroxypropanoyl)-7,8-dihydro-1H-pty oeridin-4-one; 2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE; 2-amino-6-[(2S)-2-hydroxypropanoyl]-7,8-dihydro-1H-pteridin
Molecular FormulaC9H11N5O3
Molecular Weight237.215
Purity96+
Density1.9±0.1 g/cm3
Boiling Point448.1ºC at 760 mmHg
Melting Point> 275 °C (lit.)
Appearanceyellow solid
Storage ConditionSealed in a cool, dry environment at -20 ºC
ApplicationL-Sepiapterin (Sepiapterin) is the precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves mesenteric arteriolar endothelial dysfunction an
EINECS0
HTC2933990090
UN(IATA)0
SMILESCC(O)C(=O)C1=Nc2c(nc(N)[nH]c2=O)NC1
InChIInChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,5,7,11,15H,2H2,1H3,(H3,10,13,14,17)
InChI KeyVPVOXUSPXFPWBN-VKHMYHEASA-N
Hazard Symbolstransportation
MSDSmsds/101314_2_17094_01_8.pdf
BioactivityL-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2]. Related Catalog Research Areas >> Cancer Target Human Endogenous Metabolite In Vitro L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner[1]. L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K[1]. L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism[1]. Cell Proliferation Assay[1] Cell Line: SKOV-3 cells Concentration: 0.1, 1, 10 μM Incubation Time: 24 hours Result: Induced cell proliferation in a dose-dependent manner. In Vivo Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice[2]. Animal Model: Male C57BL/KsJ diabetic mice (db/db)[2] Dosage: 10 mg/kg Administration: P.o. (powder chow); daily for or 8 weeks Result: Significantly improved the relaxation to Ach in SMA from db/db mice. References [1]. Pannirselvam M, et al. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol. 2003;140(4):701‐706. [2]. Cho YR, et al. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep. 2011;26(4):861‐867. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 448.1ºC at 760 mmHg Melting Point > 275 °C (lit.) Molecular Formula C9H11N5O3 Molecular Weight 237.215 Flash Point 224.8ºC Exact Mass 237.086182 PSA 133.46000 LogP -3.93 Vapour Pressure 6.54E-10mmHg at 25°C Index of Refraction 1.822 InChIKey VPVOXUSPXFPWBN-VKHMYHEASA-N SMILES CC(O)C(=O)C1=Nc2c(nc(N)[nH]c2=O)NC1 Storage condition 20°C
Use ofL-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2]. Properties Articles39 Name sepiapterin Synonym More Synonyms L-Sepiapterin Biological Activity Description L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2]. Related Catalog Research Areas >> Cancer Human Endogenous Metabolite References [1]. Pannirselvam M, et al. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol. 2003;140(4):701‐706. [2]. Cho YR, et al. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep. 2011;26(4):861‐867. Chemical & Physical Properties Molecular Formula C9H11N5O3 Exact Mass 237.086182 PSA 133.46000 LogP -3.93 Index of Refraction 1.822 InChIKey VPVOXUSPXFPWBN-VKHMYHEASA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
Related Products in Pharmaceutical Intermediates
(S)-2-AMINO-4-((3-CARBOXYPROPANOYL)OXY)BUTANOIC ACID1492-23-52A-0101295
(S)-2-AMINO-4-(2-FORMAMIDOPHENYL)-4-OXOBUTANOIC ACID3978-11-82A-0101296
(S)-2-AMINO-4-BROMOBUTANOIC ACID HYDROCHLORIDE1187453-22-02A-0101302
(S)-2-AMINO-4-METHYL-N-(4-NITROPHENYL)PENTANAMIDE HYDROCHLORIDE16010-98-32A-0101305
(S)-2-AMINO-5-(3-PROPYLGUANIDINO)PENTANOIC ACID137361-05-82A-0101308
(S)-2-AMINO-6-HYDROXYHEXANOIC ACID6033-32-52A-1101315
(S)-2-AMINO-8-(TERT-BUTOXY)-8-OXOOCTANOIC ACID276869-42-22A-0101317
(S)-2-AMINO-N-((S)-1-AMINO-1-OXO-3-PHENYLPROPAN-2-YL)-3-METHYLBUTANAMIDE HYDROCHLORIDE129678-27-92A-0101318
(S)-2-AMINO-N-((S)-3-METHYL-2-OXO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-1-YL)PROPANAMIDE253136-72-02A-0101319
(S)-2-AMINO-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)PROPANAMIDE77471-41-12A-0101320
Browse all Pharmaceutical Intermediates products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA