CAS Number61-12-1
Synonyms2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride (1:1); Dibucaine hydrochloride; MFCD00012735; Benzolin (VAN); Cincaine; benzolin; 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Monohydrochloride; 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1); EINECS 200-498-1; 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide hydrochloride (1:1); 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide,hydrochloride; Dibucaine HCl; Dibucaine (hydrochloride)
Molecular FormulaC20H30ClN3O2
Molecular Weight379.92
Purity≥99%
Density1.071g/cm3
Boiling Point496.3ºC at 760 mmHg
Melting Point99-101 °C (lit.)
Appearancewhite powder
EINECS200-498-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61-12-1 |
| Catalog No. | 2A-9010108 |
| Chinese Name | 盐酸辛可卡因 |
| Synonyms | 2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride (1:1); Dibucaine hydrochloride; MFCD00012735; Benzolin (VAN); Cincaine; benzolin; 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Monohydrochloride; 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1); EINECS 200-498-1; 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide hydrochloride (1:1); 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide,hydrochloride; Dibucaine HCl; Dibucaine (hydrochloride) |
| Molecular Formula | C20H30ClN3O2 |
| Molecular Weight | 379.92 |
| Purity | ≥99 |
| Density | 1.071g/cm3 |
| Boiling Point | 496.3ºC at 760 mmHg |
| Melting Point | 99-101 °C (lit.) |
| Appearance | white powder |
| Storage Condition | This product should be sealed and stored in a dry |
| Application | Dibucaine hydrochloride has local anesthetic activity. |
| EINECS | 200-498-1 |
| HTC | 2934999090 |
| PubChem ID | 24893282 |
| MDL Number | MFCD00012735 |
| SMILES | Cl[H].CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 |
| InChI | 1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H |
| InChI Key | IVHBBMHQKZBJEU-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10108_1_61_12_1.pdf |
| Bioactivity | Dibucaine Hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia.Target: Sodium ChannelDibucaine is an amide local anesthetic. Dibucaine reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain [1].Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Natural Products >> Others References [1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20. [2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53. Chemical & Physical Properties Density 1.071g/cm3 Boiling Point 496.3ºC at 760 mmHg Melting Point 99-101 °C(lit.) Molecular Formula C20H30ClN3O2 Molecular Weight 379.924 Flash Point 254ºC Exact Mass 379.202667 PSA 54.46000 LogP 4.67820 InChIKey IVHBBMHQKZBJEU-UHFFFAOYSA-N SMILES CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1.Cl Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| Use of | Properties Name cinchocaine hydrochloride Synonym More Synonyms Dibucaine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Natural Products >> Others References [1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20. [2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53. Chemical & Physical Properties Exact Mass 379.202667 PSA 54.46000 LogP 4.67820 InChIKey IVHBBMHQKZBJEU-UHFFFAOYSA-N Storage condition Refrigerator Stability Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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