CAS Number17355-11-2
SynonymsH-Tyr-Phe-OH; Tyr-Phe; L-tyrosyl-L-phenylalanine; tyrosylphenylalanine; tyrosinylphenylalanine; L-Tyrosine-L-phenylalanine
Molecular FormulaC18H20N2O4
Molecular Weight328.37
Purity96+%
Density1.3 g/cm3
Boiling Point642.2ºC at 760 mmHg
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 17355-11-2 |
| Catalog No. | 2A-0101024 |
| Chinese Name | L-酪氨酰-L-苯丙氨酸 |
| Synonyms | H-Tyr-Phe-OH; Tyr-Phe; L-tyrosyl-L-phenylalanine; tyrosylphenylalanine; tyrosinylphenylalanine; L-Tyrosine-L-phenylalanine |
| Molecular Formula | C18H20N2O4 |
| Molecular Weight | 328.37 |
| Purity | 96+ |
| Density | 1.3 g/cm3 |
| Boiling Point | 642.2ºC at 760 mmHg |
| Application | H-Tyr-Phe-OH (L-tyrosyl-L-phenylalanine) is an orally active angiotensin-converting enzyme (ACE) inhibitor with an inhibition rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as a biomarker to different |
| EINECS | 0 |
| HTC | 2924299090 |
| UN(IATA) | 0 |
| MDL Number | C18H20N2O4 |
| SMILES | NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)O |
| InChI Key | CGWAPUBOXJWXMS-HOTGVXAUSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/101024_1_17355_11_2.pdf |
| Bioactivity | H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Target Target: ACE (Angiotensin converting enzyme), xanthine oxidase[1] References [1]. Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01. [2]. Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE)-inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16. [3]. Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22. [4]. Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250. Chemical & Physical Properties Density 1.3 g/cm3 Boiling Point 642.2ºC at 760 mmHg Molecular Formula C18H20N2O4 Molecular Weight 328.36200 Flash Point 342.2ºC Exact Mass 328.14200 PSA 112.65000 LogP 2.16530 Vapour Pressure 2.27E-17mmHg at 25°C Index of Refraction 1.625 InChIKey CGWAPUBOXJWXMS-HOTGVXAUSA-N SMILES NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)O |
| Use of | H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4]. Properties Name 2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoic acid Synonym More Synonyms Tyr-Phe Biological Activity Description H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Target: ACE (Angiotensin converting enzyme), xanthine oxidase[1] References [1]. Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01. [2]. Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE)-inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16. [3]. Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22. [4]. Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250. Chemical & Physical Properties Molecular Formula C18H20N2O4 Exact Mass 328.14200 PSA 112.65000 LogP 2.16530 Index of Refraction 1.625 InChIKey CGWAPUBOXJWXMS-HOTGVXAUSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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