CAS Number13739-02-1
Synonyms4,5-Diacetoxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; DIACERHEIN; MFCD00468030; DIACETYL RHEIN; Fisiodar; 4,5-diacetylrhein; Rhein Diacetate; 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; SF 277; rhein,diacetate; Diacerein; 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid; artrodar; Diacereine; EINECS 237-310-2; DAR; 4,5-Diacetoxyanthraquinone-2-carboxylic Acid; diacetylrhein
Molecular FormulaC19H12O8
Molecular Weight368.29
Purity≥95 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point631.5±55.0 °C at 760 mmHg
Melting Point217-2180C
Appearancepowder
EINECS237-310-2
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13739-02-1 |
| Catalog No. | 2A-9010091 |
| Chinese Name | 双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸 |
| Synonyms | 4,5-Diacetoxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; DIACERHEIN; MFCD00468030; DIACETYL RHEIN; Fisiodar; 4,5-diacetylrhein; Rhein Diacetate; 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; SF 277; rhein,diacetate; Diacerein; 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid; artrodar; Diacereine; EINECS 237-310-2; DAR; 4,5-Diacetoxyanthraquinone-2-carboxylic Acid; diacetylrhein |
| Molecular Formula | C19H12O8 |
| Molecular Weight | 368.29 |
| Purity | ≥95 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 631.5±55.0 °C at 760 mmHg |
| Melting Point | 217-2180C |
| Appearance | powder |
| Storage Condition | Refrigerator |
| Application | Diacerein is an interleukin-1β inhibitor and a slow-acting anthraquinone compound. |
| EINECS | 237-310-2 |
| HTC | 2918990090 |
| PubChem ID | 24894281 |
| MDL Number | MFCD00468030 |
| SMILES | CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O |
| InChI | 1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25) |
| InChI Key | TYNLGDBUJLVSMA-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 41116107 |
| MSDS | msds/10091_1_13739_02_1.pdf |
| Use of | Diacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.Target: IL-1 betaDiacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models, together with analgesic and anti-inflammatory properties. Due to its excellent gastro-intestinal tolerance, a combination therapy with an analgesic or a NSAID may be recommended during the first 2-4 weeks of treatment. From Wikipedia. Properties Name 1,8-Diacetoxy-3-carboxyanthraquinone Synonym More Synonyms Diacerein Biological Activity Description Diacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.Target: IL-1 betaDiacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models, together with analgesic and anti-inflammatory properties. Due to its excellent gastro-intestinal tolerance, a combination therapy with an analgesic or a NSAID may be recommended during the first 2-4 weeks of treatment. From Wikipedia. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Natural Products >> Quinones References [1]. http://en.wikipedia.org/wiki/Diacerein Chemical & Physical Properties Molecular Formula C19H12O8 Exact Mass 368.053223 PSA 124.04000 Index of Refraction 1.634 InChIKey TYNLGDBUJLVSMA-UHFFFAOYSA-N Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, diacetate CAS REGISTRY NUMBER : 13739-02-1 BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H12-O8 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L C666 BV IVJ DOV1 FVQ NOV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P305 + P351 + P338 Hazard Codes Xi Safety Phrases 26-36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS CB8781000 HS Code 2918990090 Synthetic Route Ethanoic anhydr... 13739-02-1 Literature: Gonnot, Vanessa; Tisserand, Steve; Nicolas, Marc; Baati, Rachid; Mioskowski, Charles Tetrahedron Letters, 2007 , vol. 48, # 40 p. 7117 - 7119 1418885-46-7 13739-02-1 potassium salt ... 112118-18-0 13739-02-1 Literature: EP2196450 A1, ; Page/Page column 6 ; Precursor & DownStream Precursor 8 CAS#:478-43-3 CAS#:108-24-7 Ethanoic anhydride CAS#:112118-18-0 potassium salt ... CAS#:820243-52-5 (2,4-dibromo-6-... DownStream 2 CAS#:478-43-3 CAS#:72049-24-2 4,5-dimethoxy-9... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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