CAS Number24584-09-6
Synonyms4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione; (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione; 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion; 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione); (+)-4,4'-Propylenedi-2,6-piperazinedione; Dexrazoxane; Desrazoxane; Razoxane (+)-form; (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione; Eucardion; MFCD00866449; (+)-dexrazoxane; 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione; (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
Molecular FormulaC11H16N4O4
Molecular Weight268.27
Purity≥97.0 (GC)%
Density1.3±0.1 g/cm3
Boiling Point531.5±50.0 °C at 760 mmHg
Melting Point194-196ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 24584-09-6 |
| Catalog No. | 2A-9010083 |
| Chinese Name | 右雷佐生 |
| Synonyms | 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione; (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione; 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion; 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione); (+)-4,4'-Propylenedi-2,6-piperazinedione; Dexrazoxane; Desrazoxane; Razoxane (+)-form; (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione; Eucardion; MFCD00866449; (+)-dexrazoxane; 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione; (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione |
| Molecular Formula | C11H16N4O4 |
| Molecular Weight | 268.27 |
| Purity | ≥97.0 (GC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 531.5±50.0 °C at 760 mmHg |
| Melting Point | 194-196ºC |
| Storage Condition | Desiccate at RT |
| Application | Dexrazoxane (ICRF187) is a cardioprotective agent. |
| HTC | 2933599090 |
| PubChem ID | 329748105 |
| MDL Number | MFCD00866449 |
| SMILES | C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
| InChI | 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1 |
| InChI Key | BMKDZUISNHGIBY-ZETCQYMHSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10083_1_24584_09_6.pdf |
| Bioactivity | Dexrazoxane(ICRF187) is a cardioprotective agent.Target: OthersDexrazoxane is a cardioprotective agent. Dexrazoxane is a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. The exact chelation mechanism is unknown, but it has be postulated that dexrazoxane can be converted into ring-opened form intracellularly and interfere with iron-mediated free radical generation that is in part thought to be responsible for anthryacycline induced cadiomyopathy. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs [1, 2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Jones, R.L., Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7. [2]. Loyevsky, M., et al., Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol, 1999. 91(2): p. 105-14. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 531.5±50.0 °C at 760 mmHg Melting Point 194-196ºC Molecular Formula C11H16N4O4 Molecular Weight 268.269 Flash Point 275.3±30.1 °C Exact Mass 268.117157 PSA 98.82000 LogP -0.37 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.540 InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N SMILES CC(CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 Storage condition Desiccate at RT |
| Use of | Dexrazoxane(ICRF187) is a cardioprotective agent.Target: OthersDexrazoxane is a cardioprotective agent. Dexrazoxane is a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. The exact chelation mechanism is unknown, but it has be postulated that dexrazoxane can be converted into ring-opened form intracellularly and interfere with iron-mediated free radical generation that is in part thought to be responsible for anthryacycline induced cadiomyopathy. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs [1, 2]. Properties Articles35 Name (+)-dexrazoxane Synonym More Synonyms Dexrazoxane Biological Activity Description Dexrazoxane(ICRF187) is a cardioprotective agent.Target: OthersDexrazoxane is a cardioprotective agent. Dexrazoxane is a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. The exact chelation mechanism is unknown, but it has be postulated that dexrazoxane can be converted into ring-opened form intracellularly and interfere with iron-mediated free radical generation that is in part thought to be responsible for anthryacycline induced cadiomyopathy. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs [1, 2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease References [1]. Jones, R.L., Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther, 2008. 6(10): p. 1311-7. [2]. Loyevsky, M., et al., Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol, 1999. 91(2): p. 105-14. Chemical & Physical Properties Molecular Formula C11H16N4O4 Exact Mass 268.117157 PSA 98.82000 LogP -0.37 Index of Refraction 1.540 InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N Storage condition Desiccate at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards Right Lei Zuosheng Modification number: 4 Module 14. Shipping information UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Dexloxiglumide | 119817-90-2 | 2A-9010078 |
| Dexmedetomidine | 113775-47-6 | 2A-9010079 |
| Dexmedetomidine HCl | 145108-58-3 | 2A-9010080 |
| Dexpemedolac | 114030-44-3 | 2A-9010081 |
| Dexproxibutene | 47419-52-3 | 2A-9010082 |
| Dextilidine | 32447-90-8 | 2A-9010085 |
| Dextran sulfate sodium | 9011-18-1 | 2A-9010086 |
| Dextranomer | 56087-11-7 | 2A-9010087 |
| Dextromethorphan | 125-71-3 | 2A-9010088 |
| Dextromethorphan hydrobromide | 125-69-9 | 2A-9010089 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS