CAS Number113775-47-6
SynonymsDexmedetomidine; 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; Dexmedetomidina; (S)-medetomidine; Dexmedetomidinum
Molecular FormulaC13H16N2
Molecular Weight200.28
Purity98%
Density1.053g/cm3
Boiling Point381.9ºC at 760mmHg
Melting Point146-149°C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 113775-47-6 |
| Catalog No. | 2A-9010079 |
| Chinese Name | 右美托嘧啶 |
| Synonyms | Dexmedetomidine; 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; Dexmedetomidina; (S)-medetomidine; Dexmedetomidinum |
| Molecular Formula | C13H16N2 |
| Molecular Weight | 200.28 |
| Purity | 98 |
| Density | 1.053g/cm3 |
| Boiling Point | 381.9ºC at 760mmHg |
| Melting Point | 146-149°C |
| Storage Condition | 2-8°C |
| Application | Dexmedetomidine (+-medetomidine) is a potent, selective, and orally active α2-adrenoceptor agonist with a Ki of 1.08 nM. Dexmedetomidine is 1620-fold selective for α1-adrenergic receptors. Dexmedetomi |
| HTC | 2933290090 |
| MDL Number | C13H16N2 |
| SMILES | Cc1cccc(C(C)c2cnc[nH]2)c1C |
| InChI | InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 |
| InChI Key | CUHVIMMYOGQXCV-NSHDSACASA-N |
| MSDS | msds/10079_1_113775_47_6.pdf |
| Use of | Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3]. Properties Name dexmedetomidine Synonym More Synonyms Dexmedetomidine Biological Activity Description Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease α2-adrenergic receptor:1.08 nM (Ki) In Vitro Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine[1]. Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0[1]. References [1]. Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14. [2]. Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001 Jan;14(1):13-21. [3]. Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019;35(1):36-40. Chemical & Physical Properties Molecular Formula C13H16N2 Exact Mass 200.13100 PSA 28.68000 LogP 3.17830 Index of Refraction 1.569 InChIKey CUHVIMMYOGQXCV-NSHDSACASA-N Safety Information HS Code 2933290090 Synthetic Route (S)-4-(1-(2,3-d... CAS#:176721-04-3 Dexmedetomidine CAS#:113775-47-6 2,3-Dimethylbro... CAS#:576-23-8 Dexmedetomidine CAS#:113775-47-6 Literature: Synthetic Communications, , vol. 26, # 8 p. 1585 - 1593 (2,3-DIMETHYLPH... CAS#:176721-02-1 Dexmedetomidine CAS#:113775-47-6 Literature: Synthetic Communications, , vol. 26, # 8 p. 1585 - 1593 Precursor & DownStream Precursor 4 CAS#:576-23-8 2,3-Dimethylbro... CAS#:176721-02-1 (2,3-DIMETHYLPH... CAS#:176721-01-0 α-(2,3-Dimethyl... CAS#:176721-03-2 1'-Hydroxy N-Tr... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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