CAS Number58-28-6
Synonyms5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, hydrochloride (1:1); Desipramine hydrochloride; Desimipramine Hydrochloride; MFCD00058108; irene; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine,hydrochloride; EINECS 200-373-1; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride (1:1); Desipramine HCl; 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride; N-(g-Methylaminopropyl)iminodibenzyl Hydrochloride; RMI 9384A; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-aminhydrochlorid; N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine hydrochloride (1:
Molecular FormulaC18H23ClN2
Molecular Weight302.84
Purity≥98 (TLC)%
Boiling Point407.4ºC at 760 mmHg
Melting Point214-216ºC
Appearancepowder
EINECS200-373-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58-28-6 |
| Catalog No. | 2A-0201181 |
| Chinese Name | 去甲丙咪嗪盐酸盐 |
| Synonyms | 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, hydrochloride (1:1); Desipramine hydrochloride; Desimipramine Hydrochloride; MFCD00058108; irene; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine,hydrochloride; EINECS 200-373-1; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride (1:1); Desipramine HCl; 10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride; N-(g-Methylaminopropyl)iminodibenzyl Hydrochloride; RMI 9384A; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-aminhydrochlorid; N-(γ-Methylaminopropyl)iminodibenzyl hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine hydrochloride (1: |
| Molecular Formula | C18H23ClN2 |
| Molecular Weight | 302.84 |
| Purity | ≥98 (TLC) |
| Boiling Point | 407.4ºC at 760 mmHg |
| Melting Point | 214-216ºC |
| Appearance | powder |
| Water Solubility | H2O: 50 mg/mL |
| Storage Condition | 2-8°C |
| Application | Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), serotonin transporter (SERT) and dopamine transporter (DAT) with Ki values of 4, 61 and 78,720 nM, respectively. |
| EINECS | 200-373-1 |
| PubChem ID | 24278094 |
| MDL Number | MFCD00058108 |
| SMILES | Cl[H].CNCCCN1c2ccccc2CCc3ccccc13 |
| InChI | 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H |
| InChI Key | XAEWZDYWZHIUCT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352116 |
| Hazard Symbols | Transport |
| MSDS | msds/10051_1_58_28_6.pdf |
| Bioactivity | Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease Target Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)[1] In Vivo Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)[2]. Animal Admin Rats are anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg) and implanted subcutaneously with osmotic minipumps preloaded with either vehicle (50% saline, 40% DMSO, and 10% ethanol) or Desipramine hydrochloride at a concentration that delivered 5, 10, or 15 mg/kg per day of the free base. Minipumps are removed, under anesthesia, 14 days later. Rats are tested for antidepressant-like behavior in the forced-swim test 2 to 8 days after pump removal and discontinuation of Desipramine hydrochloride treatment. Following the completion of the behavioral tests, rats are killed by decapitation, their brains are removed, and cerebral cortex and hippocampus are dissected for neurochemical analyses[2]. References [1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25. [2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200. Chemical & Physical Properties Boiling Point 407.4ºC at 760 mmHg Melting Point 214-216ºC Molecular Formula C18H23ClN2 Molecular Weight 302.842 Flash Point 160.5ºC Exact Mass 302.154968 PSA 15.27000 LogP 4.79070 InChIKey XAEWZDYWZHIUCT-UHFFFAOYSA-N SMILES CNCCCN1c2ccccc2CCc2ccccc21.Cl Storage condition 2-8°C Water Solubility H2O: 50 mg/mL |
| Use of | Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively. Properties Articles69 Name desipramine hydrochloride Synonym More Synonyms Desipramine hydrochloride Biological Activity Description Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)[1] In Vivo Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)[2]. References [2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200. Chemical & Physical Properties Exact Mass 302.154968 PSA 15.27000 LogP 4.79070 InChIKey XAEWZDYWZHIUCT-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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