CAS Number522-51-0
SynonymsQuinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride; DECA; efisol; dekamin; evazol; le chlorure de dequalinium; dekadin; EINECS 208-330-9; 1,1'-Decan-1,10-diylbis(4-amino-2-methylchinolinium)dichlorid; BADQ-10; 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium) dichloride; dequadin; eriosept; 1,1'-Decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride; Dequalinium Chloride; dequavet; baqd10; Dequadin chloride; Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2); MFCD00063502; Dequalinium (Chloride)
Molecular FormulaC30H40Cl2N4
Molecular Weight527.57
Purity98%
Melting Point≥300 °C (lit.)
Appearancepowder
EINECS208-330-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 522-51-0 |
| Catalog No. | 2A-9010047 |
| Chinese Name | 地喹氯铵 |
| Synonyms | Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride; DECA; efisol; dekamin; evazol; le chlorure de dequalinium; dekadin; EINECS 208-330-9; 1,1'-Decan-1,10-diylbis(4-amino-2-methylchinolinium)dichlorid; BADQ-10; 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium) dichloride; dequadin; eriosept; 1,1'-Decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride; Dequalinium Chloride; dequavet; baqd10; Dequadin chloride; Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2); MFCD00063502; Dequalinium (Chloride) |
| Molecular Formula | C30H40Cl2N4 |
| Molecular Weight | 527.57 |
| Purity | 98 |
| Melting Point | ≥300 °C (lit.) |
| Appearance | powder |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Application | Dequalinium chloride is an apamin-sensitive potassium channel selective blocker. |
| EINECS | 208-330-9 |
| HTC | 2933499090 |
| PubChem ID | 329823288 |
| MDL Number | MFCD00063502 |
| SMILES | [Cl-].[Cl-].Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 |
| InChI | 1S/C30H38N4.2ClH/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3;2*1H |
| InChI Key | LTNZEXKYNRNOGT-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10047_1_522_51_0.pdf |
| Bioactivity | Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Infection References [1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10. [2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5. Chemical & Physical Properties Melting Point ≥300 °C(lit.) Molecular Formula C30H40Cl2N4 Molecular Weight 527.571 Exact Mass 526.263000 PSA 59.80000 LogP 1.34060 InChIKey LTNZEXKYNRNOGT-UHFFFAOYSA-N SMILES Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21.[Cl-].[Cl-] Storage condition 2-8°C |
| Use of | Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2]. Properties Articles27 Name dequalinium chloride Synonym More Synonyms Dequalinium Chloride Biological Activity Description Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Infection References [1]. Kramer, W., [Treatment of tonsillitis with dequalinium chloride]. Fortschr Med, 1977. 95(16): p. 1108-10. [2]. Gamboa-Vujicic, G., et al., Toxicity of the mitochondrial poison dequalinium chloride in a murine model system. J Pharm Sci, 1993. 82(3): p. 231-5. Chemical & Physical Properties Exact Mass 526.263000 PSA 59.80000 LogP 1.34060 InChIKey LTNZEXKYNRNOGT-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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