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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (R)-N6-PROPYL-4,5,6,7-TETRAHYDROBENZO[D]THIAZOLE-2,6-DIAMINE
(R)-N6-PROPYL-4,5,6,7-TETRAHYDROBENZO[D]THIAZOLE-2,6-DIAMINE structure, CAS 104632-28-2

(R)-N6-PROPYL-4,5,6,7-TETRAHYDROBENZO[D]THIAZOLE-2,6-DIAMINE

CAS Number104632-28-2

SynonymsDexpramipexole; (6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole; (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine; (6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine; (R)-Pramipexole Dihydrochloride; Pramipexole [USAN:INN]; (R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole; (R)-Pramipexole; (R)-(+)-pramipexole

Molecular FormulaC10H17N3S1

Molecular Weight211.33

Purity96+%

Density1.17±0.1 g/cm3

Boiling Point

Melting Point270-272ºC

Flash Point

Appearance

EINECS0

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Symbol

Signal Word

Cat. No.: 2A-0100322 Purity: 96+%
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Quality Control of [ 104632-28-2 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number104632-28-2
Catalog No.2A-0100322
Chinese Name(R)-普拉克索
SynonymsDexpramipexole; (6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole; (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine; (6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine; (R)-Pramipexole Dihydrochloride; Pramipexole [USAN:INN]; (R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole; (R)-Pramipexole; (R)-(+)-pramipexole
Molecular FormulaC10H17N3S1
Molecular Weight211.33
Purity96+
Density1.17±0.1 g/cm3
Melting Point270-272ºC
Water SolubilitySlightly soluble (1.1 g/L) (25 ºC)
Storage ConditionRoom temperature, dry, sealed
ApplicationDexpramipexole (KNS-760704), also called R-(+)-Pramipexole, is a neuroprotective agent and a weak non-ergot dopamine receptor agonist.
EINECS0
HTC2934999090
UN(IATA)0
MDL NumberMFCD09033169
SMILESCCCNC1CCc2nc(N)sc2C1
InChI KeyFASDKYOPVNHBLU-SSDOTTSWSA-N
MSDSmsds/100322_1_104632_28_2.pdf
Use ofDexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. Properties Name (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Synonym More Synonyms Dexpramipexole Biological Activity Description Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotroph Lateral Scler [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11. [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6. [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85. [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20. Chemical & Physical Properties Molecular Formula C10H17N3S PSA 83.52000 LogP 4.38490 InChIKey FASDKYOPVNHBLU-SSDOTTSWSA-N Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route (R)-(+)-2-amino... CAS#:1332723-78-0 Dexpramipexole CAS#:104632-28-2 (R)-N-(2-AMINO-... CAS#:106006-85-3 Dexpramipexole CAS#:104632-28-2 Literature: Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498 D-Tartaric acid CAS#:147-71-7 (±)-Pramipexole CAS#:104617-86-9 Dexpramipexole CAS#:104632-28-2 Pramipexole CAS#:104632-26-0 Precursor & DownStream Precursor 5 CAS#:106006-85-3 (R)-N-(2-AMINO-... CAS#:147-71-7 D-Tartaric acid CAS#:104617-86-9 (±)-Pramipexole CAS#:106092-11-9 (+)-(6R)-2,6-di... DownStream 0
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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