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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (R)-4-((DIETHYLAMINO)METHYL)-N-(2-METHOXYPHENETHYL)-N-(PYRROLIDIN-3-YL)BENZAMIDE
(R)-4-((DIETHYLAMINO)METHYL)-N-(2-METHOXYPHENETHYL)-N-(PYRROLIDIN-3-YL)BENZAMIDE structure, CAS 947303-87-9

(R)-4-((DIETHYLAMINO)METHYL)-N-(2-METHOXYPHENETHYL)-N-(PYRROLIDIN-3-YL)BENZAMIDE

CAS Number947303-87-9

Synonyms4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]benzamide; 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide; PF-429242

Molecular FormulaC25H35N3O2

Molecular Weight482.49

Purity≥98 (HPLC)%

Density1.1±0.1 g/cm3

Boiling Point562.2±50.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS0

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-0099965 Purity: ≥98 (HPLC)%
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Quality Control of [ 947303-87-9 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number947303-87-9
Catalog No.2A-0099965
Chinese Name(R)-4-((二乙基胺)甲基)-N-(2-甲氧基苯乙基)- 4-[(二乙基氨基)甲基]-N-[2-(2-甲氧基苯基)乙基]-N-(3R)-3-吡咯烷基苯甲酰胺 二盐酸盐
Synonyms4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]benzamide; 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide; PF-429242
Molecular FormulaC25H35N3O2
Molecular Weight482.49
Purity≥98 (HPLC)
Density1.1±0.1 g/cm3
Boiling Point562.2±50.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20℃
ApplicationPF429242 is a reversible, competitive inhibitor of SREBP site 1 protease (S1P) with an IC50 value of 175 nM.
EINECS0
HTC2933990090
UN(IATA)0
SMILESN1C[C@@H](CC1)N(CCc3c(cccc3)OC)C(=O)c2ccc(cc2)CN(CC)CC
InChI1S/C25H35N3O2/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3/h6-13,23,26H,4-5,14-19H2,1-3H3/t23-/m1/s1
InChI KeyXKPJTOHUPQWSOJ-HSZRJFAPSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
MSDSmsds/99965_1_947303_87_9.pdf
BioactivityPF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Infection Research Areas >> Metabolic Disease References [1]. Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. [2]. Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. [3]. Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 562.2±50.0 °C at 760 mmHg Molecular Formula C25H35N3O2 Molecular Weight 409.56 Flash Point 293.8±30.1 °C Exact Mass 409.272919 PSA 44.81000 LogP 2.88 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.586 InChIKey XKPJTOHUPQWSOJ-HSZRJFAPSA-N SMILES CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 Storage condition -20℃
Use ofPF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Properties Name (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide Synonym More Synonyms PF-429242 Biological Activity Description PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS) Research Areas >> Infection Research Areas >> Metabolic Disease References [1]. Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. [2]. Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. [3]. Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803. Chemical & Physical Properties Molecular Formula C25H35N3O2 Exact Mass 409.272919 PSA 44.81000 Index of Refraction 1.586 InChIKey XKPJTOHUPQWSOJ-HSZRJFAPSA-N Storage condition -20℃
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (PF-429242 dihydrochloride) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (PF-429242 dihydrochloride) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (PF-429242 dihydrochloride) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3),
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