CAS Number79094-20-5
Synonyms4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid; [4-[2-(4-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid; 2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid; 4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID; DatelliptiumChloride; 2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid; 4-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenylacetic acid; 4-((((4-chlorophenyl)sulfonyl)amino)ethyl)benzene acetic acid; MFCD00868295
Molecular FormulaC16H16ClNO4S
Molecular Weight353.82
Purity>98 (HPLC)%
Density1.378g/cm3
Boiling Point555.3ºC at 760 mmHg
Melting Point132.5-137.4 °C (lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 79094-20-5 |
| Catalog No. | 2A-9009992 |
| Chinese Name | 达尔卓潘 |
| Synonyms | 4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid; [4-[2-(4-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid; 2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid; 4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID; DatelliptiumChloride; 2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid; 4-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenylacetic acid; 4-((((4-chlorophenyl)sulfonyl)amino)ethyl)benzene acetic acid; MFCD00868295 |
| Molecular Formula | C16H16ClNO4S |
| Molecular Weight | 353.82 |
| Purity | >98 (HPLC) |
| Density | 1.378g/cm3 |
| Boiling Point | 555.3ºC at 760 mmHg |
| Melting Point | 132.5-137.4 °C (lit.) |
| Appearance | solid |
| Water Solubility | DMSO: 22 mg/mL, soluble |
| Storage Condition | Room temperature, sealed, dry |
| Application | Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increases intracellular calcium in vascular smooth muscle. Daltroban has protective effects agains |
| PubChem ID | 24724468 |
| MDL Number | MFCD00868295 |
| SMILES | OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1 |
| InChI | 1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20) |
| InChI Key | IULOBWFWYDMECP-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9992_1_79094_20_5.pdf |
| Bioactivity | Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Target TXA2 In Vivo Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats[2]. In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis[3]. Animal Model: Adult male cats (2.8 to 4.6 kg; anesthetized cat model)[2] Dosage: 1 mg/kg Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour Result: Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand. References [1]. Miki I, et al. Differences in activities of thromboxane A2 receptor antagonists in smooth muscle cells. Eur J Pharmacol. 1992 Oct 1;227(2):199-204. [2]. Thiemermann C, et al. The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. Eur J Pharmacol. 1988 Oct 11;155(1-2):57-67. [3]. Bhat AM, et al. Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats. Am Heart J. 1989 Apr;117(4):799-803. Chemical & Physical Properties Density 1.378g/cm3 Boiling Point 555.3ºC at 760 mmHg Melting Point 132.5-137.4 °C(lit.) Molecular Formula C16H16ClNO4S Molecular Weight 353.82100 Flash Point 289.6ºC Exact Mass 353.04900 PSA 91.85000 LogP 3.95980 Appearance of Characters white Vapour Pressure 3.63E-13mmHg at 25°C Index of Refraction 1.609 InChIKey IULOBWFWYDMECP-UHFFFAOYSA-N SMILES O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1 Water Solubility DMSO: 22 mg/mL, soluble |
| Use of | Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2]. Properties Articles25 Name Daltroban Synonym More Synonyms Daltroban Biological Activity Description Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor References [1]. Miki I, et al. Differences in activities of thromboxane A2 receptor antagonists in smooth muscle cells. Eur J Pharmacol. 1992 Oct 1;227(2):199-204. [2]. Thiemermann C, et al. The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. Eur J Pharmacol. 1988 Oct 11;155(1-2):57-67. [3]. Bhat AM, et al. Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats. Am Heart J. 1989 Apr;117(4):799-803. Chemical & Physical Properties Exact Mass 353.04900 PSA 91.85000 LogP 3.95980 Appearance of Characters white Index of Refraction 1.609 InChIKey IULOBWFWYDMECP-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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