CAS Number23593-75-1
Synonyms1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole; Gyne-Lotrimin; Empecid; Rimazole; 1-[(2-chlorophenyl)-diphenylmethyl]imidazole; 1-(o-Chlorotrityl)imidazole,1-(o-Chl; Trimysten; 1-[(o-Chlorophenyl)diphenylmethyl]imidazole; Tibatin; 1-(2-Chlorotrityl)imidazole; 1H-Imidazole, 1-[(2-chlorophenyl)-diphenylmethyl]; Canifug; Canesten; Mycelex G; Mycelex; 1-(o-Chlorotrityl)imidazole; Mycosporin; 1-[a-(2-Chlorophenyl)benzhydryl]imidazole; Pedisafe; Mono-baycuten; 1-[(2-Chlorophenyl)diphenylmethyl]imidazole; 1-(o-Chloro-a,a-diphenylbenzyl)imidazole; Fungicip; MFCD00057220; UNII-G07GZ97H65; EINECS 245-764-8; 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole; Lotrimin; Clotrimazole; Clotrimazole crystalline
Molecular FormulaC22H17ClN2
Molecular Weight344.84
Purity98%
Density1.1±0.1 g/cm3
Boiling Point482.3±40.0 °C at 760 mmHg
Melting Point147-149ºC
Appearancepowder
EINECS245-764-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 23593-75-1 |
| Catalog No. | 2A-9009882 |
| Chinese Name | 克霉唑 |
| Synonyms | 1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole; Gyne-Lotrimin; Empecid; Rimazole; 1-[(2-chlorophenyl)-diphenylmethyl]imidazole; 1-(o-Chlorotrityl)imidazole,1-(o-Chl; Trimysten; 1-[(o-Chlorophenyl)diphenylmethyl]imidazole; Tibatin; 1-(2-Chlorotrityl)imidazole; 1H-Imidazole, 1-[(2-chlorophenyl)-diphenylmethyl]; Canifug; Canesten; Mycelex G; Mycelex; 1-(o-Chlorotrityl)imidazole; Mycosporin; 1-[a-(2-Chlorophenyl)benzhydryl]imidazole; Pedisafe; Mono-baycuten; 1-[(2-Chlorophenyl)diphenylmethyl]imidazole; 1-(o-Chloro-a,a-diphenylbenzyl)imidazole; Fungicip; MFCD00057220; UNII-G07GZ97H65; EINECS 245-764-8; 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole; Lotrimin; Clotrimazole; Clotrimazole crystalline |
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.84 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 482.3±40.0 °C at 760 mmHg |
| Melting Point | 147-149ºC |
| Appearance | powder |
| Water Solubility | Soluble in chloroform, DMSO, DMF and alcohols |
| Storage Condition | Store in a compact container in a cool, dry place |
| Application | Clotrimazole is an imidazole derivative with antifungal activity and a P450 inhibitor. |
| EINECS | 245-764-8 |
| HTC | 2933290012 |
| PubChem ID | 24278327 |
| MDL Number | MFCD00057220 |
| SMILES | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 |
| InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H |
| InChI Key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9882_1_23593_75_1.pdf |
| Bioactivity | Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection References [1]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47. [2]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 482.3±40.0 °C at 760 mmHg Melting Point 147-149ºC Molecular Formula C22H17ClN2 Molecular Weight 344.837 Flash Point 245.5±27.3 °C Exact Mass 344.108032 PSA 17.82000 LogP 5.44 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.617 InChIKey VNFPBHJOKIVQEB-UHFFFAOYSA-N SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 Storage condition Store at RT. Water Solubility Soluble in chloroform, DMSO, DMF and alcohols |
| Use of | Properties Articles158 Name clotrimazole Synonym More Synonyms Clotrimazole Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection References [1]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47. [2]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32. Chemical & Physical Properties Exact Mass 344.108032 PSA 17.82000 Index of Refraction 1.617 InChIKey VNFPBHJOKIVQEB-UHFFFAOYSA-N Storage condition Store at RT. Water Solubility Soluble in chloroform, DMSO, DMF and alcohols |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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