CAS Number132203-70-4
SynonymsASTA 3746; Atelec; Ciclonium bromide; Siscard; MFCD00865853; Cicloniumbromid; Cinalong; Cilnidipine
Molecular FormulaC27H28O7N2
Molecular Weight492.53
Purity98%
Density1.2±0.1 g/cm3
Boiling Point652.6±55.0 °C at 760 mmHg
Melting Point97-99°C
AppearanceYellow crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 132203-70-4 |
| Catalog No. | 2A-9009790 |
| Chinese Name | 西尼地平 |
| Synonyms | ASTA 3746; Atelec; Ciclonium bromide; Siscard; MFCD00865853; Cicloniumbromid; Cinalong; Cilnidipine |
| Molecular Formula | C27H28O7N2 |
| Molecular Weight | 492.53 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 652.6±55.0 °C at 760 mmHg |
| Melting Point | 97-99°C |
| Appearance | Yellow crystalline solid |
| Storage Condition | Store at +4°C |
| Application | Cilnidipine (FRC8653) is an L-type and N-type calcium ion blocker with antihypertensive and neuroprotective activities. |
| HTC | 2933399090 |
| MDL Number | MFCD00865853 |
| SMILES | COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC=Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1 |
| InChI | InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+ |
| InChI Key | KJEBULYHNRNJTE-DHZHZOJOSA-N |
| MSDS | msds/9790_1_132203_70_4.pdf |
| Bioactivity | Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. IC50 value:Target: calcium channelCilnidipine has displayed renal and vascular protective effects and improved baroreflex sensitivity in patients with hypertension. It has also demonstrated neuroprotective effects in a rat focal brain ischemia model by removing free radicals and activating the phosphatidylinositol 3-kinase pathway. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10 [2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83. [3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91. [4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 652.6±55.0 °C at 760 mmHg Melting Point 97-99°C Molecular Formula C27H28N2O7 Molecular Weight 492.520 Flash Point 348.5±31.5 °C Exact Mass 492.189636 PSA 119.68000 LogP 5.36 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.592 InChIKey KJEBULYHNRNJTE-DHZHZOJOSA-N SMILES COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC=Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1 Storage condition Store at +4°C |
| Use of | Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. IC50 value:Target: calcium channelCilnidipine has displayed renal and vascular protective effects and improved baroreflex sensitivity in patients with hypertension. It has also demonstrated neuroprotective effects in a rat focal brain ischemia model by removing free radicals and activating the phosphatidylinositol 3-kinase pathway. Properties Articles28 Name cilnidipine Synonym More Synonyms Cilnidipine Biological Activity Description Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. IC50 value:Target: calcium channelCilnidipine has displayed renal and vascular protective effects and improved baroreflex sensitivity in patients with hypertension. It has also demonstrated neuroprotective effects in a rat focal brain ischemia model by removing free radicals and activating the phosphatidylinositol 3-kinase pathway. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10 [2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine in patients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83. [3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004 Sep;27(9):1388-91. [4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10. Chemical & Physical Properties Molecular Formula C27H28N2O7 Exact Mass 492.189636 PSA 119.68000 Index of Refraction 1.592 InChIKey KJEBULYHNRNJTE-DHZHZOJOSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Ciglitazone | 74772-77-3 | 2A-9009784 |
| Cilastatin sodium | 81129-83-1 | 2A-9009785 |
| Cilazapril | 88768-40-5 | 2A-9009786 |
| Cilazaprilat | 90139-06-3 | 2A-9009787 |
| Cilmostim | 148637-05-2 | 2A-9009789 |
| Cilobradine | 109859-50-9 | 2A-9009791 |
| Cilostazol | 73963-72-1 | 2A-9009792 |
| Ciltoprazine | 54063-30-8 | 2A-9009793 |
| Cilutazoline | 104902-08-1 | 2A-9009794 |
| Cimetropium bromide | 51598-60-8 | 2A-9009797 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS