CAS Number53267-01-9
SynonymsCibenzolinum [inn-latin]; UP 33-901; Cibenzolinum; Exacor; 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole; Cibenzolina; Cibenol; 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole; Ro 22-7796; [15N]-Cibenzoline; Cifenline
Molecular FormulaC18H18N2
Molecular Weight380.44
Purity≥98 (HPLC)%
Density1.17 g/cm3
Boiling Point449.2ºC
Melting Point103-104°
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53267-01-9 |
| Catalog No. | 2A-9009771 |
| Chinese Name | Ro 22-7796 |
| Synonyms | Cibenzolinum [inn-latin]; UP 33-901; Cibenzolinum; Exacor; 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole; Cibenzolina; Cibenol; 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole; Ro 22-7796; [15N]-Cibenzoline; Cifenline |
| Molecular Formula | C18H18N2 |
| Molecular Weight | 380.44 |
| Purity | ≥98 (HPLC) |
| Density | 1.17 g/cm3 |
| Boiling Point | 449.2ºC |
| Melting Point | 103-104° |
| Appearance | solid |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Cibenzoline is an effective inhibitor of KATP channels and directly affects the pore formation of Kir6. 2 subunit instead of SUR1 subunit. Cibenzoline is a Class Ia antiarrhythmic drug. Cylbenzoline h |
| HTC | 2933290090 |
| PubChem ID | 24892426 |
| MDL Number | MFCD00941423 |
| SMILES | OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4 |
| InChI | 1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8) |
| InChI Key | XFUIOIWYMHEPIE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/9771_1_53267_01_9.pdf |
| Use of | Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2]. Properties Name Cibenzoline Synonym More Synonyms Cibenzoline Biological Activity Description Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel KATP channel[1] References [1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481. [2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524. Chemical & Physical Properties Molecular Formula C18H18N2 Exact Mass 262.14700 PSA 24.39000 LogP 2.75870 Index of Refraction 1.655 InChIKey IPOBOOXFSRWSHL-UHFFFAOYSA-N Safety Information HS Code 2933290090 Synthetic Route Total: 1 Page 1-cyano-2,2-dip... CAS#:28098-84-2 1,2-Ethanediamine CAS#:107-15-3 Cibenzoline CAS#:53267-01-9 Literature: Gholap, Atul R.; Paul, Vincent; Srinivasan, Kumar V. Synthetic Communications, 2008 , vol. 38, # 17 p. 2967 - 2982 Precursor & DownStream Precursor 2 CAS#:28098-84-2 1-cyano-2,2-dip... CAS#:107-15-3 1,2-Ethanediamine DownStream 1 CAS#:85589-36-2 2-(2,2-diphenyl... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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