| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70797-11-4 |
| Catalog No. | 2A-9009660 |
| Chinese Name | 头孢匹胺 |
| Synonyms | CEFPIRAMIDE; Cefpiramide acid |
| Molecular Formula | C25H24O7N8S2 |
| Molecular Weight | 612.65 |
| Purity | 98 |
| Density | 1.75 g/cm3 |
| Melting Point | 213-215° (dec) |
| Appearance | White or off-white crystalline powder |
| Storage Condition | -20 °C, inert gas |
| Application | Cefepamide (SM-1652) free acid is a semi-synthetic cephalosporin with broad-spectrum antibacterial activity. Cefepamide free acid has a strong antibacterial effect on both Gram-positive and Gram-negat |
| HTC | 3003201900 |
| MDL Number | MFCD00864893 |
| SMILES | Cc1cc(=O)c(C(=O)NC(C(=O)NC2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CSC23)c2ccc(O)cc2)c[nH]1 |
| InChI | InChI=1S/C25H24N8O7S2.Na/c1-11-7-16(35)15(8-26-11)20(36)27-17(12-3-5-14(34)6-4-12)21(37)28-18-22(38)33-19(24(39)40)13(9-41-23(18)33)10-42-25-29-30-31-32(25)2;/h3-8,17-18,23,34H,9-10H2,1-2H3,(H,26,35)(H,27,36)(H,28,37)(H,39,40);/q;+1/p-1/t17?,18-,23-;/m1./s1 |
| InChI Key | PWAUCHMQEXVFJR-PMAPCBKXSA-N |
| MSDS | msds/9660_1_70797_11_4.pdf |
| Use of | Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2]. Properties Name cefpiramide Synonym More Synonyms Cefpiramide acid Biological Activity Description Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Bacterial[1][2] In Vitro Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1]. Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1]. Cell Viability Assay[1] Cell Line: 761 bacterial isolates (35 different species of common bacterial pathogens) Concentration: 0-2048 µg/mL Incubation Time: 16-18 hours Result: Showed broad-spectrum antibacterial activity. References [1]. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25. [2]. Sato K, et al. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 1984 Oct;26(4):578-9. Chemical & Physical Properties Molecular Formula C25H24N8O7S2 Exact Mass 612.12100 PSA 263.36000 LogP 1.04640 Index of Refraction 1.821 InChIKey PWAUCHMQEXVFJR-PMAPCBKXSA-N Safety Information RIDADR NONH for all modes of transport HS Code 3003201900 |
| Transport Info | Product Name: Cefopiramide |
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