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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > (2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC ACID
(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC ACID structure, CAS 169209-63-6

(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC ACID

CAS Number169209-63-6

Synonyms4-amino-2,4-pyrrolidinedicarboxylic acid; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid

Molecular FormulaC6H10N2O4

Molecular Weight174.15500

Purity96+%

Density

Boiling Point

Melting Point

Flash Point

Appearance

EINECS0

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Cat. No.: 2A-0095239 Purity: 96+%
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Quality Control of [ 169209-63-6 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number169209-63-6
Catalog No.2A-0095239
Chinese Name(2R,4R)-APDC
Synonyms4-amino-2,4-pyrrolidinedicarboxylic acid; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
Molecular FormulaC6H10N2O4
Molecular Weight174.15500
Purity96+
Storage Conditionroom temperature, dry
Application(2R,4R)-APDC is a selective class II metabotropic glutamate receptor (mGluRs). (2R,4R)-APDC has anticonvulsant and neuroprotective effects.
EINECS0
HTC0
UN(IATA)0
PubChem ID7978587
MDL NumberMFCD25977777
SMILESNC1(C(=O)O)CNC(C(=O)O)C1
InChIInChI=1S/C6H10N2O4/c7-6(5(11)12)1-3(4(9)10)8-2-6/h3,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,6-/m1/s1
InChI KeyXZFMJVJDSYRWDQ-AWFVSMACSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/95239_1_169209_63_6.pdf
Bioactivity(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease In Vivo 2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2]. Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2] Dosage: 1 nmol/10 μl; 10 nmol/10μl Administration: ICV; daily for 14 days Result: Resulted in decreased BrdU-immunoreactive cells in the DG. References [1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. Chemical & Physical Properties Molecular Formula C6H10N2O4 Molecular Weight 174.15500 Exact Mass 174.06400 PSA 112.65000 InChIKey XZFMJVJDSYRWDQ-AWFVSMACSA-N SMILES NC1(C(=O)O)CNC(C(=O)O)C1
Use of(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects[1][2]. Properties Name 2R, 4R-APDC monohydrate Synonym More Synonyms (2R,4R)-APDC Biological Activity Description (2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects[1][2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease References [1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. Chemical & Physical Properties Molecular Formula C6H10N2O4 Exact Mass 174.06400 PSA 112.65000 InChIKey XZFMJVJDSYRWDQ-AWFVSMACSA-N SMILES NC1(C(=O)O)CNC(C(=O)O)C1
Transport InfoProduct name: (2R,4R)-APDC
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