CAS Number64872-76-0
SynonymsBUTONAZOLE; 1-{4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl}-1H-imidazole; 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole; Butoconazole; 1-[4-(4-chloro-phenyl)-2-(2,6-dichloro-phenylsulfanyl)-butyl]-1H-imidazole; Butooonazole; (±)-1-[4-(4-chlorophenyl)-2[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole; 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)butyl]imidazole; 1-[2-[(2,6-Dichlorophenyl)thio]-4-(4-chlorophenyl)butyl]-1H-imidazole; (±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; Gynomyk; MFCD00865616; exelgyn
Molecular FormulaC19H17Cl3N2S
Molecular Weight411.78
Purity98%
Density1.3±0.1 g/cm3
Boiling Point566.9±50.0 °C at 760 mmHg
Melting Point68-70.5ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64872-76-0 |
| Catalog No. | 2A-9009512 |
| Chinese Name | 布康唑 |
| Synonyms | BUTONAZOLE; 1-{4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl}-1H-imidazole; 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)-n-butyl]imidazole; Butoconazole; 1-[4-(4-chloro-phenyl)-2-(2,6-dichloro-phenylsulfanyl)-butyl]-1H-imidazole; Butooonazole; (±)-1-[4-(4-chlorophenyl)-2[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenyl)sulfanyl-butyl]imidazole; 1-[2-(2,6-dichlorophenylthio)-4-(4-chlorophenyl)butyl]imidazole; 1-[2-[(2,6-Dichlorophenyl)thio]-4-(4-chlorophenyl)butyl]-1H-imidazole; (±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole; Gynomyk; MFCD00865616; exelgyn |
| Molecular Formula | C19H17Cl3N2S |
| Molecular Weight | 411.78 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 566.9±50.0 °C at 760 mmHg |
| Melting Point | 68-70.5ºC |
| Appearance | powder |
| Storage Condition | -20℃ |
| Packaging | II |
| Application | Butoconazole is an imidazole antifungal agent active against Candida species and effective against vaginal infections caused by Candida albicans. Butoconazole is thought to act like other imidazole de |
| HTC | 2933290090 |
| MDL Number | C19H17Cl3N2S |
| SMILES | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 |
| InChI | InChI=1S/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2 |
| InChI Key | SWLMUYACZKCSHZ-UHFFFAOYSA-N |
| Hazard Symbols | 8 |
| MSDS | msds/9512_1_64872_76_0.pdf |
| Use of | Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2]. Properties Articles25 Name butoconazole Synonym More Synonyms Butoconazole Biological Activity Description Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal In Vitro Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell[1]. References [1]. Anik ST, et al. Extreme vertexes design in formulation development: solubility of butoconazole nitrate in a multicomponent system. J Pharm Sci. 1981;70(8):897-900. [2]. Pharmacology refers to the chemical makeup and behavior of GYNAZOLE 1 (butoconazole nitrate cream). Chemical & Physical Properties Exact Mass 410.017792 PSA 43.12000 Index of Refraction 1.634 InChIKey SWLMUYACZKCSHZ-UHFFFAOYSA-N Storage condition -20℃ Safety Information Hazard Codes C WGK Germany 3 Packaging Group II Hazard Class 8 HS Code 2933290090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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