CAS Number101828-21-1
Synonyms1-[4-(1,1-diméthyléthyl)phényl]-N-méthyl-N-(naphtalén-1-ylméthyl)méthanamine chlorhydrate; Butenafine hydrochloride; 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride; Butenafine HCl; Butenafina; 1-(4-tert-Butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanaminhydrochlorid; Butenafinum; Butenafina [INN-Spanish]; 1-(4-tert-Butylphenyl)-N-methyl-N-(1-naphthylmethyl)methanamine; 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine; MFCD00865577; Mentax; Butenafine; 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1); N-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride; 1-naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride; N-M
Molecular FormulaC23H27N
Molecular Weight353.93
Purity≥98 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point426.1±14.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 101828-21-1 |
| Catalog No. | 2A-9009504 |
| Chinese Name | 布替萘芬 |
| Synonyms | 1-[4-(1,1-diméthyléthyl)phényl]-N-méthyl-N-(naphtalén-1-ylméthyl)méthanamine chlorhydrate; Butenafine hydrochloride; 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride; Butenafine HCl; Butenafina; 1-(4-tert-Butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanaminhydrochlorid; Butenafinum; Butenafina [INN-Spanish]; 1-(4-tert-Butylphenyl)-N-methyl-N-(1-naphthylmethyl)methanamine; 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine; MFCD00865577; Mentax; Butenafine; 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1); N-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride; 1-naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride; N-M |
| Molecular Formula | C23H27N |
| Molecular Weight | 353.93 |
| Purity | ≥98 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 426.1±14.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | Room temperature, sealed, dry |
| Application | Butenafine is a potent broad-spectrum benzylamine antifungal agent. Butenafine inhibits fungal ergosterol biosynthesis at the squalene epoxidation site, leading to defects in fungal cell membrane form |
| HTC | 2921199090 |
| PubChem ID | 329773252 |
| MDL Number | MFCD00917064 |
| SMILES | Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23 |
| InChI | 1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H |
| InChI Key | LJBSAUIFGPSHCN-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/9504_1_101828_21_1.pdf |
| Use of | Butenafine is a potent and broad spectrum benzylamine antifungal agent[1]. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as tinea pedis, tinea cruris, tinea versicolor[1][2]. Properties Name butenafine Synonym More Synonyms Butenafine Biological Activity Description Butenafine is a potent and broad spectrum benzylamine antifungal agent[1]. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as tinea pedis, tinea cruris, tinea versicolor[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal IC50: antifungal[1] References [1]. Katrina Kokjohn, et al. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria.Int J Dermatol. 2003 Sep;42 Suppl 1:11-7. [2]. Adriana Bezerra-Souza, et al. The antifungal compound butenafine eliminates promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. 2016 Dec;65(6 Pt A):702-707. [3]. Topical Antifungal Agent. Butenafine Chemical & Physical Properties Molecular Formula C23H27N Exact Mass 317.214355 PSA 3.24000 Index of Refraction 1.598 InChIKey ABJKWBDEJIDSJZ-UHFFFAOYSA-N Safety Information HS Code 2921199090 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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