| Chemical & Physical Properties | |
|---|---|
| CAS Number | 14556-46-8 |
| Catalog No. | 2A-9009492 |
| Chinese Name | 布拉洛尔 |
| Synonyms | Ophtorenin; Bupranol |
| Molecular Formula | C14H22O2N1Cl1 |
| Molecular Weight | 271.79 |
| Purity | 98.00 |
| Density | 1.098g/cm3 |
| Boiling Point | 396.3ºC at 760mmHg |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Buparol is an orally active, competitive and non-selective beta-adrenoceptor antagonist with no intrinsic sympathomimetic activity [1]. |
| HTC | 2922509090 |
| MDL Number | MFCD00864591 |
| SMILES | Cc1ccc(Cl)c(OCC(O)CNC(C)(C)C)c1 |
| InChI | InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3 |
| InChI Key | HQIRNZOQPUAHHV-UHFFFAOYSA-N |
| MSDS | msds/9492_1_14556_46_8.pdf |
| Use of | Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1]. Properties Name Bupranolol Synonym More Synonyms Bupranolol Biological Activity Description Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology β-adrenoceptor In Vitro Bupranolol (1~3 μM) shifts isoprenaline-induced relaxation in the presence of 30 μM propranolol. Bupranolol acts as a competitive antagonist of isoprenaline-induced relaxation in the presence of 300 nM propranolol, with a pA2 value of 5.90. Bupranolol antagonizes β1- and β2-ARs with pA2 values of ≈9.0, and also antagonizes β3-AR with a pA2 value of 6.0[1]. References [1]. Chino D, et al. Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. J Smooth Muscle Res. 2018;54(0):13-27. [2]. Babu RJ, et al. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm. 2004;271(1-2):155-165. Chemical & Physical Properties Exact Mass 271.13400 PSA 41.49000 LogP 3.16710 Index of Refraction 1.522 InChIKey HQIRNZOQPUAHHV-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Propanol, 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)- CAS REGISTRY NUMBER : 14556-46-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H22-Cl-N-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : 1X1&1&M1YQ1OR BG E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977 Safety Information HS Code 2922509090 |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Bunazosin hydrochloride | 52712-76-2 | 2A-9009487 |
| Bunitrolol | 34915-68-9 | 2A-9009488 |
| Bunolol | 27591-01-1 | 2A-9009489 |
| Buphenine | 447-41-6 | 2A-9009490 |
| Bupivacaine hydrochloride | 14252-80-3 | 2A-9009491 |
| Buquineran | 59184-78-0 | 2A-9009494 |
| Burodiline | 36121-13-8 | 2A-9009495 |
| Buserelin | 57982-77-1 | 2A-9009496 |
| Butalamine | 22131-35-7 | 2A-9009499 |
| Butanserin | 87051-46-5 | 2A-9009501 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS