| Chemical & Physical Properties | |
|---|---|
| CAS Number | 916210-98-5 |
| Catalog No. | 2A-0094744 |
| Chinese Name | 2-氯-4-氨甲基吡啶盐酸盐 |
| Synonyms | (2-chloropyridin-4-yl)methanamine,hydrochloride; 1-(2-Chloro-4-pyridinyl)methanamine hydrochloride (1:1); 4-Pyridinemethanamine, 2-chloro-, hydrochloride (1:1) |
| Molecular Formula | C6H8Cl2N2 |
| Molecular Weight | 179.05 |
| Purity | 96+ |
| Storage Condition | 2-8°C, store in inert gas |
| Application | LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 value of 126 nM. |
| EINECS | 0 |
| HTC | 2933399090 |
| UN(IATA) | 0 |
| PubChem ID | 152223861 |
| InChI | InChI=1S/C6H7ClN2.ClH/c7-6-3-5(4-8)1-2-9-6;/h1-3H,4,8H2;1H |
| InChI Key | BWSUKLOBJGMGCJ-UHFFFAOYSA-N |
| Bioactivity | LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease Target IC50: 126 nM (LOXL2)[1] In Vitro LOXL2-IN-1 is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, LOXL2-IN-1 has an IC50 of 1.45 µM compared to 126 nM in the absence of blood proteins. LOXL2-IN-1 shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. LOXL2-IN-1 is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 µM[1]. References [1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. Chemical & Physical Properties Molecular Formula C6H8Cl2N2 Molecular Weight 179.047 Exact Mass 178.006454 PSA 38.91000 LogP 2.69600 |
| Use of | LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. Properties Name (2-Chloropyridin-4-yl)methanamine hydrochloride Synonym More Synonyms Biological Activity Description LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease IC50: 126 nM (LOXL2)[1] References [1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. Chemical & Physical Properties Exact Mass 178.006454 PSA 38.91000 LogP 2.69600 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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