| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22978-25-2 |
| Catalog No. | 2A-9094002 |
| Chinese Name | 2-氯-5-硝基-N-苯基苯酰胺 |
| Synonyms | MFCD01215270; 2-Chloro-5-nitro-N-phenylbenzamide; GW-9662; GW9662 |
| Molecular Formula | C13H9ClN2O3 |
| Molecular Weight | 276.68 |
| Purity | >98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 360.9±32.0 °C at 760 mmHg |
| Melting Point | 171-175 °C(lit.) |
| Appearance | powder |
| Water Solubility | DMSO: 26 mg/mL, soluble |
| Storage Condition | 2-8℃ |
| Application | GW9662 is a potent, selective PPARγ antagonist with an IC50 value of 3.3 nM, which is 10-fold and 1000-fold more selective than PPARα and PPARδ. |
| HTC | 2924299090 |
| PubChem ID | 24278560 |
| MDL Number | MFCD01215270 |
| SMILES | [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccccc2 |
| InChI | 1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17) |
| InChI Key | DNTSIBUQMRRYIU-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/94002_1_22978_25_2.pdf |
| Use of | GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. Properties Articles46 Name 2-Chloro-5-nitro-N-4-phenylbenzamide Synonym More Synonyms GW9662 Biological Activity Description GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Cancer PPARγ:3.3 nM (IC50) PPARα:32 nM (IC50) PPARδ:2000 nM (IC50) References [1]. Leesnitzer LM, et al. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry. 2002 May 28;41(21):6640-50. [2]. Seargent JM, et al. GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. Br J Pharmacol. 2004 Dec;143(8):933-7. [3]. Sato K, et al. PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.Haematologica. 2016 Jan;101(1):57-67. [4]. Collino M, et al. The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int. 2005 Aug;68(2):529-36. Chemical & Physical Properties Exact Mass 276.030182 PSA 74.92000 Appearance of Characters solid | white Index of Refraction 1.676 InChIKey DNTSIBUQMRRYIU-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H317-H319 Precautionary Statements P280-P305 + P351 + P338 Hazard Codes Xi Risk Phrases R36;R43 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2924299090 Synthetic Route Total: 1 Page 2-Chloro-5-nitr... CAS#:25784-91-2 CAS#:74497-02-2 CAS#:22978-25-2 Literature: Henke, Adam; Srogl, Jiri Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7783 - 7784 2-Chloro-5-nitr... CAS#:2516-96-3 CAS#:74497-02-2 CAS#:22978-25-2 Literature: Kumar, Anil; Narasimhan, Balasubramanian; Kumar, Devinder Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 12 p. 4113 - 4124 Diethyl ether CAS#:60-29-7 Phosphorus pent... CAS#:10026-13-8 N-[(2-chloro-5-... CAS#:141883-38-7 CAS#:22978-25-2 Literature: Justus Liebigs Annalen der Chemie, , vol. 446, p. 225 Precursor & DownStream Precursor 5 CAS#:25784-91-2 2-Chloro-5-nitr... CAS#:2516-96-3 2-Chloro-5-nitr... CAS#:60-29-7 Diethyl ether CAS#:10026-13-8 Phosphorus pent... DownStream 0 Preparation |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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