CAS Number1038915-60-4
Synonymspound notMK4827 pound not MK 4827; 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide; Niraparib; MK4827; 2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxamide; UNII:HMC2H89N35; MK-4827
Molecular FormulaC19H20O1N4
Molecular Weight320.39
Density1.3±0.1 g/cm3
Boiling Point463.6±45.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1038915-60-4 |
| Catalog No. | 2A-9093867 |
| Chinese Name | 尼拉帕尼 |
| Synonyms | pound notMK4827 pound not MK 4827; 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide; Niraparib; MK4827; 2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxamide; UNII:HMC2H89N35; MK-4827 |
| Molecular Formula | C19H20O1N4 |
| Molecular Weight | 320.39 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 463.6±45.0 °C at 760 mmHg |
| Storage Condition | -20°C |
| Application | Niraparib (MK-4827) is a highly potent PARP1 and PARP2 inhibitor with IC50 of 3.8 nM and 2.1 nM respectively. |
| HTC | 2933990090 |
| PubChem ID | 56256045 |
| MDL Number | MFCD17779309 |
| SMILES | NC(=O)c1cccc2cn(-c3ccc(C4CCCNC4)cc3)nc12 |
| InChI | InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1 |
| InChI Key | PCHKPVIQAHNQLW-CQSZACIVSA-N |
| MSDS | msds/93867_1_1038915_60_4.pdf |
| Use of | Niraparib (MK-4827) is a highly potent PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Properties Name 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide Synonym More Synonyms MK-4827(Niraparib) Biological Activity Description Niraparib (MK-4827) is a highly potent PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cancer PARP-2:2.1 nM (IC50) PARP-1:3.8 nM (IC50) V-PARP:330 nM (IC50) TANK-1:570 nM (IC50) PARP-3:1300 nM (IC50) References [2]. Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86. Chemical & Physical Properties Molecular Formula C19H20N4O Exact Mass 320.163696 PSA 73.93000 Index of Refraction 1.705 InChIKey PCHKPVIQAHNQLW-CQSZACIVSA-N Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page 3-{4-[7-(aminoc... CAS#:1038915-56-8 MK-4827(Niraparib) CAS#:1038915-60-4 MK-4827 (R-enan... CAS#:1038915-58-0 Precursor & DownStream Precursor 1 CAS#:1038915-56-8 3-{4-[7-(aminoc... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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