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Beta-amanitin

Name: Beta-amanitin
Brand: 2A Biotech
SKU: 2A-9009374

CAS Number21150-22-1

SynonymsMFCD00151212; 8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide; EINECS 244-244-8; B-amanitin from amanita phalloides; B-Amanitine; ,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3

Molecular FormulaC39H53N9O15S

Molecular Weight919.95400

Purity98.00%

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9009374 Purity: 98.00%

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Quality Control of [ 21150-22-1 ] Purity: 98.00% SDS Specification MoL

Chemical & Physical Properties
CAS Number	21150-22-1
Catalog No.	2A-9009374
Chinese Name	β-鹅膏菌素
Synonyms	MFCD00151212; 8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide; EINECS 244-244-8; B-amanitin from amanita phalloides; B-Amanitine; ,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3
Molecular Formula	C39H53N9O15S
Molecular Weight	919.95400
Purity	98.00
Storage Condition	Sealed in a cool, dry environment at -20 ºC
Application	Beta-Amanitin is a cyclic peptide toxin found in poisonous mushrooms. β-Amanitin inhibits eukaryotic RNA polymerase II and III (RNA polymerase II/III). β-Amanitin inhibits protein synthesis. β-Amaniti
SMILES	CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(=O)O)C(=O)N1CC(O)CC1C(=O)NC(C(C)C(O)CO)C(=O)N2
InChI	InChI=1S/C39H53N9O15S/c1-4-16(2)31-36(60)41-11-28(53)42-25-15-64(63)38-21(20-6-5-18(50)7-22(20)45-38)9-23(33(57)40-12-29(54)46-31)43-37(61)32(17(3)27(52)14-49)47-35(59)26-8-19(51)13-48(26)39(62)24(10-30(55)56)44-34(25)58/h5-7,16-17,19,23-27,31-32,45,49-52H,4,8-15H2,1-3H3,(H,40,57)(H,41,60)(H,42,53)(H,43,61)(H,44,58)(H,46,54)(H,47,59)(H,55,56)
InChI Key	IEQCUEXVAPAFMQ-FPRDJREJSA-N
Hazard Symbols	6.1(a)
MSDS	msds/9374_2_21150_22_1.pdf
Bioactivity	β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Target Traditional Cytotoxic Agents In Vitro β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2]. β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 0.01, 0.1, 1, 10, 100 µg/mL Incubation Time: 36 hours Result: Showed toxicity in MCF-7 cells. References [1]. Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44(5):728-32. [2]. Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24. Chemical & Physical Properties Molecular Formula C39H53N9O15S Molecular Weight 919.95400 Exact Mass 919.33800 PSA 394.30000 Index of Refraction 1.695 InChIKey IEQCUEXVAPAFMQ-FPRDJREJSA-N SMILES CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(=O)O)C(=O)N1CC(O)CC1C(=O)NC(C(C)C(O)CO)C(=O)N2
Use of	β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. Properties Articles13 Name β-AMANITIN Synonym More Synonyms beta-Amanitin Biological Activity Description β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Traditional Cytotoxic Agents References [2]. Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24. Chemical & Physical Properties Molecular Formula C39H53N9O15S Exact Mass 919.33800 PSA 394.30000 Index of Refraction 1.695 InChIKey IEQCUEXVAPAFMQ-FPRDJREJSA-N
Transport Info	Product name: Purity: 90.0%
MSDS Transport Info	Module 14. Shipping information European Land Transport Danger Regulations: 3462 International Maritime Transport Danger Regulations: 3462 International Air Transport Danger Regulations: 3462 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. (1-L-Aspartic acid-?- amanitin) IMDG Code: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (1-L-Aspartic acid-?- amanitin) International Air Transport Risk Regulations: Toxins, extracted from living sources, solid, n.o.s. (1-L-Aspartic acid-?-amanitin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: I International Dangerous Regulations for sea transport: I International Dangerous Regulations for air transport: I 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available

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Beta-amanitin

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