| Chemical & Physical Properties | |
|---|---|
| CAS Number | 39544-74-6 |
| Catalog No. | 2A-9093686 |
| Chinese Name | 苯并曲普 |
| Synonyms | N-carbamothioyl-4-chloro-benzamide; EINECS 254-500-0; N-p-Chlorbenzoyl-thioharnstoff; (4-chloro-benzoyl)-thiourea |
| Molecular Formula | C18H15ClN2O3 |
| Molecular Weight | 342.78 |
| Purity | 98.00% |
| Boiling Point | 643.7ºC at 760 mmHg |
| Application | Benzotrop is a cholecystokinin receptor (CCK) and gastrin receptor antagonist. Benzotrop shows antiproliferative effects in human colon cancer cell lines [1]. |
| HTC | 2933990090 |
| PubChem ID | 11364600 |
| MDL Number | C18H15ClN2O3 |
| SMILES | O=C(NC(Cc1c[nH]c2ccccc12)C(=O)O)c1ccc(Cl)cc1 |
| InChI | InChI=1S/C18H15ClN2O3/c19-13-7-5-11(6-8-13)17(22)21-16(18(23)24)9-12-10-20-15-4-2-1-3-14(12)15/h1-8,10,16,20H,9H2,(H,21,22)(H,23,24)/p-1/t16-/m1/s1 |
| InChI Key | QJERBBQXOMUURJ-INIZCTEOSA-N |
| MSDS | msds/93686_1_39544_74_6.pdf |
| Use of | Benzotript (Benzotriptum) is a cholecystokinin-receptor (CCK) and gastrin receptor antagonist. Benzotript shows antiproliferative effects in human colon carcinoma cell lines[1]. Properties Name benzotript Synonym More Synonyms benzotript Biological Activity Description Benzotript (Benzotriptum) is a cholecystokinin-receptor (CCK) and gastrin receptor antagonist. Benzotript shows antiproliferative effects in human colon carcinoma cell lines[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Inflammation/Immunology References [1]. N M Hoosein, et al. Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. Cancer Res. 1988 Dec 15;48(24 Pt 1):7179-83. [2]. C Niederau, et al. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology. 1985 May;88(5 Pt 1):1192-204. Chemical & Physical Properties Exact Mass 342.07700 PSA 82.19000 LogP 3.63790 InChIKey QJERBBQXOMUURJ-INIZCTEOSA-N Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page 4-Chlorobenzoic acid CAS#:74-11-3 benzotript CAS#:39544-74-6 Literature: Burdick, Daniel J.; Marsters Jr., James C.; Aliagas-Martin, Ignacio; Stanley, Mark; Beresini, Maureen; Clark, Kevin; McDowell, Robert S.; Gadek, Thomas R. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2055 - 2059 4-Chlorobenzoyl... CAS#:122-01-0 L(-)-Tryptophan CAS#:73-22-3 benzotript CAS#:39544-74-6 Literature: Hwang, Tsong-Long; Hung, Chih-Hao; Hsu, Ching-Yun; Huang, Yin-Ting; Tsai, Yu-Chi; Hsieh, Pei-Wen Organic and Biomolecular Chemistry, 2013 , vol. 11, # 22 p. 3742 - 3755 Precursor & DownStream Precursor 3 CAS#:74-11-3 4-Chlorobenzoic acid CAS#:122-01-0 4-Chlorobenzoyl... CAS#:73-22-3 L(-)-Tryptophan DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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