CAS Number1480-19-9
SynonymsAnti-Pica; 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)-piperazine-1-yl]butan-1-one; Haloanisone; N1-(2-Methoxy-phenyl)-N4-<3-(4-fluor-benzoyl)-propyl>-piperazin; 1-(4-fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one; MD 2028; 4'-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; Fluanisonum [INN-Latin]; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone; Sedalande; Fluanison; Metorin; 4-[4-(o-Methoxyphenyl)-1-piperazinyl]-p-fluorobutyrophenone; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one; fluanisone; Haloanison
Molecular FormulaC21H25FN2O2
Molecular Weight356.44
Purity98.00%%
Density1.1±0.1 g/cm3
Boiling Point511.8±50.0 °C at 760 mmHg
Melting Point67.5-68.5°
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1480-19-9 |
| Catalog No. | 2A-9093661 |
| Chinese Name | 氟阿尼酮 |
| Synonyms | Anti-Pica; 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)-piperazine-1-yl]butan-1-one; Haloanisone; N1-(2-Methoxy-phenyl)-N4-<3-(4-fluor-benzoyl)-propyl>-piperazin; 1-(4-fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one; MD 2028; 4'-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; Fluanisonum [INN-Latin]; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone; Sedalande; Fluanison; Metorin; 4-[4-(o-Methoxyphenyl)-1-piperazinyl]-p-fluorobutyrophenone; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one; fluanisone; Haloanison |
| Molecular Formula | C21H25FN2O2 |
| Molecular Weight | 356.44 |
| Purity | 98.00% |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 511.8±50.0 °C at 760 mmHg |
| Melting Point | 67.5-68.5° |
| Appearance | solid |
| Storage Condition | -20°C |
| HTC | 2933599090 |
| PubChem ID | 443248 |
| MDL Number | C21H25FN2O2 |
| SMILES | COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1 |
| InChI | InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3 |
| InChI Key | IRYFCWPNDIUQOW-UHFFFAOYSA-N |
| MSDS | msds/93661_1_1480_19_9.pdf |
| Use of | Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania. It is also a component (along with fentanyl) of the injectable veterinary formulation fentanyl/fluanisone (Hypnorm) where it is used for rodent analgesia during short surgical procedures. Properties Name 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one Synonym More Synonyms Chemical & Physical Properties Molecular Formula C21H25FN2O2 Exact Mass 356.190002 PSA 32.78000 Index of Refraction 1.558 InChIKey IRYFCWPNDIUQOW-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Butyrophenone, 4'-fluoro-4-(4-(o-methoxyphenyl)-1-piperazinyl)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H25-F-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6N DNTJ A3VR DF& DR BO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Autonomic Nervous System - central sympatholytic Behavioral - alteration of classical conditioning REFERENCE : MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(2),199,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy) REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,159,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 32,2241,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 3,432,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,199,1980 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 Safety Information HS Code 2933599090 Synthetic Route 1-(4-p-Fluoroph... CAS#:857-62-5 fluanisone CAS#:1480-19-9 Literature: Narsaiah, A. Venkat; Nagaiah; Devi, B. Karuna Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 829 - 832 4-Fluorobenzaldehyde CAS#:459-57-4 fluanisone CAS#:1480-19-9 Literature: Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832 1‐(4‐fluorophen... CAS#:86718-78-7 fluanisone CAS#:1480-19-9 Literature: Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832 Precursor & DownStream Precursor 5 CAS#:857-62-5 1-(4-p-Fluoroph... CAS#:459-57-4 4-Fluorobenzaldehyde CAS#:86718-78-7 1‐(4‐fluorophen... CAS#:1143515-07-4 1‐[1‐(benzyloxy... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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