CAS Number37338-80-0
Synonyms3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide; Orellanin; 2,2'-bipyridine-3,3',4,4'-tetrol-1,1'-dioxide; Orellanine; 3,3',4,4'-Tetrahydroxy-2,2'-bipyridine-N,N'-dioxide
Molecular FormulaC10H8N2O6
Molecular Weight252.18
Purity96%%
Density1.777 g/cm3
Boiling Point834.615ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 37338-80-0 |
| Catalog No. | 2A-9093412 |
| Chinese Name | orellanine |
| Synonyms | 3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide; Orellanin; 2,2'-bipyridine-3,3',4,4'-tetrol-1,1'-dioxide; Orellanine; 3,3',4,4'-Tetrahydroxy-2,2'-bipyridine-N,N'-dioxide |
| Molecular Formula | C10H8N2O6 |
| Molecular Weight | 252.18 |
| Purity | 96% |
| Density | 1.777 g/cm3 |
| Boiling Point | 834.615ºC at 760 mmHg |
| Storage Condition | The warehouse is low-temperature, ventilated, dry, |
| Application | Orellanine is a fungal nephrotoxin. Orelanin is also a competitive inhibitor of alkaline phosphatase. Oleomycin induces cell death in proximal tubular cells and ccRCC cells. Oleomycin can be used in t |
| HTC | 2933399090 |
| PubChem ID | 36643232 |
| MDL Number | C10H8N2O6 |
| SMILES | O=c1ccn(O)c(-c2c(O)c(=O)ccn2O)c1O |
| InChI | InChI=1S/C10H8N2O6/c13-5-1-3-11(17)7(9(5)15)8-10(16)6(14)2-4-12(8)18/h1-4,15-18H |
| InChI Key | JGRNMEQUBVRSQR-UHFFFAOYSA-N |
| MSDS | msds/93412_1_37338_80_0.pdf |
| Use of | Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2]. Properties Name 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one Synonym More Synonyms orellanine Biological Activity Description Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase References [1]. Lyons MJ, et al. Orellanine: From Fungal Origin to a Potential Future Cancer Treatment. J Nat Prod. 2023 Jun 23;86(6):1620-1631. [2]. Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8(53):91085-91098. Chemical & Physical Properties Molecular Formula C10H8N2O6 Exact Mass 252.03800 PSA 124.92000 InChIKey JGRNMEQUBVRSQR-UHFFFAOYSA-N Safety Information HS Code 2933399090 Synthetic Route 2-(3,4-dimethox... 101664-54-4 orellanine 37338-80-0 Literature: Dehmlow, Eckehard V.; Schulz, Hans-Joachim Liebigs Annalen der Chemie, 1987 , p. 857 - 862 3,3',4,4... 101664-55-5 orellanine 37338-80-0 Literature: Tiecco, Marcello Bulletin des Societes Chimiques Belges, 1986 , vol. 95, # 11 p. 1009 - 1020 2-Chloro-3-fluo... 17282-04-1 orellanine 37338-80-0 Literature: Dehmlow, Eckehard V.; Schulz, Hans-Joachim Liebigs Annalen der Chemie, 1987 , p. 857 - 862 Precursor & DownStream Precursor 10 CAS#:101664-54-4 2-(3,4-dimethox... CAS#:101664-55-5 3,3',4,4'-Tetra... CAS#:17282-04-1 2-Chloro-3-fluo... CAS#:85386-94-3 2-Chloro-3-fluo... DownStream 1 CAS#:72016-31-0 3-hydroxy-2-(3-... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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