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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > PROCYCLIDINE HYDROCHLORIDE
PROCYCLIDINE HYDROCHLORIDE structure, CAS 1508-76-5

PROCYCLIDINE HYDROCHLORIDE

CAS Number1508-76-5

SynonymsProcyclidine hydrochloride; Procyclidine Hydrochloride; PROCYCLIDINE HYDROCHLORIDE

Molecular FormulaC19H30ClNO

Molecular Weight323.90

Purity96%%

Density

Boiling Point433.5ºC at 760 mmHg

Melting Point85.5 to 86.5ºC

Flash Point

Appearancewhite powder

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9093250 Purity: 96%%
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Quality Control of [ 1508-76-5 ] Purity: 96%% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1508-76-5
Catalog No.2A-9093250
Chinese Name丙环定盐酸盐
SynonymsProcyclidine hydrochloride; Procyclidine Hydrochloride; PROCYCLIDINE HYDROCHLORIDE
Molecular FormulaC19H30ClNO
Molecular Weight323.90
Purity96%
Boiling Point433.5ºC at 760 mmHg
Melting Point85.5 to 86.5ºC
Appearancewhite powder
Storage Condition2-8°C
ApplicationProcyclidine hydrochloride is a potent anticholinergic agent that also has NMDA antagonist properties.
HTC2933990090
PubChem ID856015
SMILESCl.OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1
InChIInChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
InChI KeyZFSPFXJSEHCTTR-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityProcyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Target NMDA Receptor[1] In Vivo Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1]. Animal Admin Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls. References [1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48. Chemical & Physical Properties Boiling Point 433.5ºC at 760 mmHg Melting Point 85.5 to 86.5ºC Molecular Formula C19H30ClNO Molecular Weight 323.90100 Flash Point 205.7ºC Exact Mass 323.20200 PSA 23.47000 LogP 4.68030 Vapour Pressure 2.76E-08mmHg at 25°C InChIKey ZFSPFXJSEHCTTR-UHFFFAOYSA-N SMILES Cl.OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1 Storage condition 2-8°C
Use ofProcyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. Properties Name procyclidine hydrochloride Synonym More Synonyms Procyclidine hydrochloride Biological Activity Description Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease NMDA Receptor[1] In Vivo Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1]. References [1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48. Chemical & Physical Properties Exact Mass 323.20200 PSA 23.47000 LogP 4.68030 InChIKey ZFSPFXJSEHCTTR-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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