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Home > Products > Food & Nutrition > Nutritional Ingredients > 25-Hydroxycholecalciferol-26,26,26,27,27,27-d6;
25-Hydroxycholecalciferol-26,26,26,27,27,27-d6; structure, CAS 78782-98-6

25-Hydroxycholecalciferol-26,26,26,27,27,27-d6;

CAS Number78782-98-6

SynonymsHidroferol-d6; Calcidiol-d6; Calcifediol-D6; 25-Hydroxyvitamin D3-d6; 25-Hydroxyvitamin D-d6; Ro 8-8892-d6; <26,27-2H6>-25-hydroxyvitamin D3; Didrogyl-d6; 25-Hydroxycholecalciferol-d6

Molecular FormulaC27H38D6O2

Molecular Weight406.67

Purity

Density

Boiling Point

Melting Point64-69°C

Flash Point

Appearanceliquid

EINECS200-578-6

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Symboltransportation

Signal WordWarning

Cat. No.: 2A-0202240 Purity:
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Quality Control of [ 78782-98-6 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number78782-98-6
Catalog No.2A-0202240
Chinese Name骨化二醇-D6
SynonymsHidroferol-d6; Calcidiol-d6; Calcifediol-D6; 25-Hydroxyvitamin D3-d6; 25-Hydroxyvitamin D-d6; Ro 8-8892-d6; <26,27-2H6>-25-hydroxyvitamin D3; Didrogyl-d6; 25-Hydroxycholecalciferol-d6
Molecular FormulaC27H38D6O2
Molecular Weight406.67
Melting Point64-69°C
Appearanceliquid
Storage ConditionAmber Vial, -20°C Freezer, Under Inert Atmosphere
ApplicationCalcifediol-D6 is the deuterated form of Calcifediol (25-hydroxy Vitamin D3), a prohormone.
EINECS200-578-6
PubChem ID152258545
MDL NumberMFCD15071183
SMILESC[C@@]12[C@](CC[C@]2([H])[C@@H](CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H])C)([H])/C(CCC1)=C/C=C3C[C@@H](O)CCC/3=C
InChI1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1/i3D3,4D3
InChI KeyJWUBBDSIWDLEOM-QFVHMXLQSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbolstransportation
MSDSmsds/92770_1_78782_98_6.pdf
BioactivityCalcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. [2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. [3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. [4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7. Chemical & Physical Properties Melting Point 64-69°C Molecular Formula C27H38D6O2 Molecular Weight 406.67400 Flash Point 14℃ Exact Mass 406.37200 PSA 40.46000 LogP 6.73390 Storage condition Amber Vial, -20°C Freezer, Under Inert Atmosphere
Use ofCalcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. Properties Name (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Synonym More Synonyms Calcifediol-D6 Biological Activity Description Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value:Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. Related Catalog Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease References [1]. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. [2]. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. [3]. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. [4]. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7. Chemical & Physical Properties Molecular Formula C27H38D6O2 Exact Mass 406.37200 PSA 40.46000 LogP 6.73390
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1170 International Maritime Transport Danger Regulations: 1170 International Air Transport Danger Regulations: 1170 14.2 United Nations shipping name European Land Transport Danger Regulations: ETHANOL SOLUTION International Maritime Dangerous Regulations: ETHANOL SOLUTION International Air Transport Danger Regulations: Ethanol solution 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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