CAS Number863329-66-2
Synonyms2'-Deoxy-2'-fluoro-2'-methyluridine; PSI-6206; URI002; Ro-2433; 2'-deoxy-2'-fluoro-2'-C-methyl-uridine; PSI6206
Molecular FormulaC10H13O5N2F1
Molecular Weight260.22
Density1.6±0.1 g/cm3
Melting Point237-238℃
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 863329-66-2 |
| Catalog No. | 2A-9092761 |
| Chinese Name | (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷 |
| Synonyms | 2'-Deoxy-2'-fluoro-2'-methyluridine; PSI-6206; URI002; Ro-2433; 2'-deoxy-2'-fluoro-2'-C-methyl-uridine; PSI6206 |
| Molecular Formula | C10H13O5N2F1 |
| Molecular Weight | 260.22 |
| Density | 1.6±0.1 g/cm3 |
| Melting Point | 237-238℃ |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | <0°C; avoid heating |
| Application | PSI-6206 is a deaminated derivative of PSI-6130, a potent and selective HCV NS5B polymerase inhibitor. PSI-6206 inhibits HCV replication inefficiently, with an EC90 of >100 μM. |
| HTC | 2934999090 |
| PubChem ID | 16400511 |
| MDL Number | MFCD19982668 |
| SMILES | CC1(F)C(O)C(CO)OC1n1ccc(=O)[nH]c1=O |
| InChI | InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1 |
| InChI Key | ARKKGZQTGXJVKW-VPCXQMTMSA-N |
| MSDS | msds/92761_1_863329_66_2.pdf |
| Use of | Properties Name (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine Synonym More Synonyms PSI-6206 Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection EC90：>100 μM (HCV replicon)[1] In Vitro PSI-6206 (RO2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay[1]. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B[2]. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase[3]. References [1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24. Chemical & Physical Properties Molecular Formula C10H13FN2O5 Exact Mass 260.080841 PSA 104.55000 LogP -0.77 Index of Refraction 1.596 InChIKey ARKKGZQTGXJVKW-VPCXQMTMSA-N Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route Total: 1 Page (2'R)-N-Benzoyl... CAS#:817204-32-3 CAS#:863329-66-2 Literature: Journal of Medicinal Chemistry, , vol. 48, # 17 p. 5504 - 5508 Precursor & DownStream Precursor 1 CAS#:817204-32-3 (2'R)-N-Benzoyl... DownStream 2 CAS#:1064684-44-1 5'-O-(isopropyl... CAS#:1190307-88-0 Sofosbuvir |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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