CAS Number85144-11-2
Synonymslithium chloride hydrate,puratronic; EINECS 231-212-3; Lithium hcloride monohydrate; Lithium chloride hydrate,Puratronic,99.9 (metals basis); LITHIUM CHLORIDE MONOHYDRATE; hydrate/monohydrateortrihydrate; LITHIUM CHLORIDE 1-HYDRATE; Lithium chloride hydrate,Puratronic(R),99.9 (metals basis); Lithium chloride,Ionization Buffer Solution,Specpure|r; MFCD00149764
Molecular FormulaLiCl · xH2O
Molecular Weight42.39 (anhydrous basis)
Purity≥99.99 trace metals basis%
Density1.21 g/mL at 20 °C
Boiling Point1382 °C
Melting Point605 °C(lit.)
Appearancecrystalline
EINECS231-212-3
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85144-11-2 |
| Catalog No. | 2A-9092354 |
| Chinese Name | 氯化锂 |
| Synonyms | lithium chloride hydrate,puratronic; EINECS 231-212-3; Lithium hcloride monohydrate; Lithium chloride hydrate,Puratronic,99.9 (metals basis); LITHIUM CHLORIDE MONOHYDRATE; hydrate/monohydrateortrihydrate; LITHIUM CHLORIDE 1-HYDRATE; Lithium chloride hydrate,Puratronic(R),99.9 (metals basis); Lithium chloride,Ionization Buffer Solution,Specpure|r; MFCD00149764 |
| Molecular Formula | LiCl · xH2O |
| Molecular Weight | 42.39 (anhydrous basis) |
| Purity | ≥99.99 trace metals basis |
| Density | 1.21 g/mL at 20 °C |
| Boiling Point | 1382 °C |
| Melting Point | 605 °C(lit.) |
| Appearance | crystalline |
| Water Solubility | H2O: soluble |
| Storage Condition | Refrigerate and airtight at 2-8°C, in a cool, dry |
| Application | Lithium chloride hydrate is an orally active mood stabilizer that is a potent viral inhibitor and immune modulator. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoti |
| EINECS | 231-212-3 |
| PubChem ID | 24857976 |
| MDL Number | MFCD00149764 |
| SMILES | [Li+].[Cl-].[H]O[H] |
| InChI | 1S/ClH.Li.H2O/h1H;;1H2/q;+1;/p-1 |
| InChI Key | VXJIMUZIBHBWBV-UHFFFAOYSA-M |
| NACRES Code | NA.23 |
| UNSPSC | 12352302 |
| Hazard Symbols | transportation |
| MSDS | msds/92354_1_85144_11_2.pdf |
| Bioactivity | Lithium chloride hydrate, an orally active stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride mood hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3]. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3 Target GSK-3β In Vitro Lithium chloride hydrate (5 and 20 mM, 36 hours) Inhibits IBV Beaudette-infected BHK Cytopathy and IBV replication in cells [1]. Lithium chloride hydrate (5 and 20 mM, 36 hours) inhibits IBV-induced apoptosis and inflammation in BHK cells [1]. Lithium chloride hydrate (1 mg/mL) increases the efficiency of induced pluripotent stem cell-derived neurospheres [4]. Lithium chloride hydrate (1.2 mM, 72 hours) protects PC12 cells from Morphine (HY-P1701)-induced apoptosis [5]. RT-PCR[1] Cell Line: BHK cells Concentration: 5 and 20 mM Incubation Time: 36 h Result: Blocked the expression of NF-κB, NLRP3, TNF-α, and IL-1β. Blocked levels of Caspase-3, Bax and increased Bcl-2 level. In Vivo Lithium chloride hydrate (60 mg/kg, i.p., twice daily) Improved Sevoflurane (SEV)-induced memory impairment in rats [2]. Lithium chloride hydrate (150 mg/kg, orally, every other day) stimulates bone formation in extraction socket repair in rats [6]. Animal Model: Rats[5] Dosage: 150 mg/kg Administration: Oral administration (p.o.), every other day Result: Produced greater proportion of newly formed bone (NB). Lowered the rate of TRAP-stained cells. Animal Model: Sevoflurane-induced memory impairment rats[2] Dosage: 60 mg/kg Administration: Intraperitoneal injection (i.p.), twice a day. Result: Reduced escape latency, increased time in the objective quadrant and raised platform crossings. Suppresses SEV-induced oxidative stress reduces and reduced SEV-induced apoptosis in the hippocampus. References [1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [2]. Dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [3]. Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45(5):605-613. [4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [5]. Sahebgharani M, et al. morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48. Chemical & Physical Properties Density 1.21 g/mL at 20 °C Boiling Point 1382 °C Melting Point 605 °C(lit.) Molecular Formula ClH2LiO Molecular Weight 60.40930 Flash Point -4 °F Exact Mass 59.99540 PSA 9.23000 Appearance of Characters beads Index of Refraction n20/D 1.381 Storage condition 2-8°C Water Solubility H2O: soluble |
| Use of | Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3]. Properties Name lithium chloride hydrate Synonym More Synonyms Lithium chloride monohydrate Biological Activity Description Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3]. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3 References [1]. Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. [2]. Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10(2):251-258. [4]. Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396(8):923-8. [5]. Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11(6):639-48. Chemical & Physical Properties Exact Mass 59.99540 PSA 9.23000 Appearance of Characters beads Water Solubility H2O: soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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